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Sigma-Aldrich

N-Lauroylsarcosine sodium salt solution

30% aqueous solution, ≥97.0% (HPLC)

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Synonym(s):
Sarcosyl, Sarkosyl NL, Sodium N-dodecanoyl-N-methylglycinate, Sodium N-lauroylsarcosinate solution
Linear Formula:
CH3(CH2)10CON(CH3)CH2COONa
CAS Number:
Molecular Weight:
293.38
Beilstein:
5322974
MDL number:
PubChem Substance ID:
NACRES:
NA.25

description

anionic

Quality Level

Assay

≥97.0% (HPLC)

quality

30% aqueous solution

mol wt

average mol wt 600

aggregation number

2

technique(s)

protein quantification: suitable

pH

7.0-9.0 (25 °C)

CMC

14.6

density

1.033 g/mL at 20 °C

cation traces

Ca: ≤20 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤10 mg/kg
K: ≤70 mg/kg
Mg: ≤10 mg/kg
Mn: ≤5 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

SMILES string

[Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O

InChI

1S/C15H29NO3.Na/c1-3-4-5-6-7-8-9-10-11-12-14(17)16(2)13-15(18)19;/h3-13H2,1-2H3,(H,18,19);/q;+1/p-1

InChI key

KSAVQLQVUXSOCR-UHFFFAOYSA-M

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N-Lauroylsarcosine sodium salt detergent for use in cell lysis

Sigma-Aldrich

L9150

N-Lauroylsarcosine sodium salt

Essential+ Grade
N-Lauroylsarcosine sodium salt BioXtra, ≥97% (TLC)

Sigma-Aldrich

L5777

N-Lauroylsarcosine sodium salt

Premium Grade
assay

≥97.0% (HPLC)

assay

≥94%

assay

≥94%

assay

≥97% (TLC)

mol wt

average mol wt 600

mol wt

micellar avg mol wt 600, average mol wt 600

mol wt

micellar avg mol wt 600

mol wt

micellar avg mol wt 600, average mol wt 600

aggregation number

2

aggregation number

2

aggregation number

2

aggregation number

2

technique(s)

protein quantification: suitable

technique(s)

oligo synthesis: suitable

technique(s)

protein purification: suitable, protein quantification: suitable

technique(s)

-

CMC

14.6

CMC

14.6 mM (20-25°C)

CMC

14.6 mM (20-25°C)

CMC

14.6 mM (20-25°C)

Application

N-Lauroylsarcosine (Sarcosyl) is an ionic surfactant useful in a wide range of solubilization and permeation applications from solubilization of membrane proteins to enhancement of skin permeability in transdermal applications.

Other Notes

Solubilization of membrane proteins; useful for rupturing of eukaryote cells in transcription studies; In the lysis of Clostridium perfringens for rapid extraction of plasmids

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 2 Inhalation - Eye Irrit. 2

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Properties of the polyoma virus transcription complex obtained from mouse nuclei.
R J Shmookler et al.
Virology, 57(1), 122-127 (1974-01-01)
D E Mahony et al.
Applied and environmental microbiology, 51(3), 521-523 (1986-03-01)
Two rapid methods were evaluated for their extraction of plasmids from Clostridium perfringens. The first method involved lysis of 1 to 2 ml of C. perfringens culture by treatment with hyaluronidase, lysozyme, and sarcosyl. DNA, extracted with phenol-chloroform, was treated
P. Gariglio et al.
Febs Letters, 44, 430-430 (1974)
Yeu-Chun Kim et al.
International journal of pharmaceutics, 352(1-2), 129-138 (2007-12-15)
To develop formulations for transdermal drug delivery, this study tested the hypothesis that the anionic surfactant, N-lauroylsarcosine (NLS), and ethanol synergistically increase skin permeability by increasing the fluidity of stratum corneum lipid structure. Skin permeability experiments showed that transdermal delivery
Rhonda I Hobb et al.
Microbiology (Reading, England), 155(Pt 3), 979-988 (2009-02-28)
Although infection with Campylobacter jejuni is one of the leading causes of gastroenteritis worldwide, relatively little is known about the factors that are required to elicit a protective immune response. The need for a vaccine against this pathogen is well

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