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L9150

Sigma-Aldrich

N-Lauroylsarcosine sodium salt

detergent for use in cell lysis

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Synonym(s):
Sodium lauroyl sarcosinate, N-Dodecanoyl-N-methylglycine sodium salt, Sarkosyl NL
Linear Formula:
CH3(CH2)10CON(CH3)CH2COONa
CAS Number:
Molecular Weight:
293.38
Beilstein:
5322974
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.52

grade

for molecular biology

Quality Level

description

anionic

product line

BioReagent

Assay

≥94%

form

powder

mol wt

micellar avg mol wt 600

aggregation number

2

technique(s)

protein purification: suitable
protein quantification: suitable

CMC

14.6 mM (20-25°C)

solubility

H2O: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow

foreign activity

DNase, RNase, none detected

storage temp.

room temp

SMILES string

[Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O

InChI

1S/C15H29NO3.Na/c1-3-4-5-6-7-8-9-10-11-12-14(17)16(2)13-15(18)19;/h3-13H2,1-2H3,(H,18,19);/q;+1/p-1

InChI key

KSAVQLQVUXSOCR-UHFFFAOYSA-M

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1 of 4

This Item
61743L5777L5125
N-Lauroylsarcosine sodium salt detergent for use in cell lysis

Sigma-Aldrich

L9150

N-Lauroylsarcosine sodium salt

Essential+ Grade
N-Lauroylsarcosine sodium salt BioUltra, for molecular biology, ≥99.0% (HPLC)

Sigma-Aldrich

61743

N-Lauroylsarcosine sodium salt

Premium Grade
N-Lauroylsarcosine sodium salt BioXtra, ≥97% (TLC)

Sigma-Aldrich

L5777

N-Lauroylsarcosine sodium salt

Premium Grade
description

anionic

description

anionic

description

anionic

description

anionic

product line

BioReagent

product line

BioUltra

product line

BioXtra

product line

-

assay

≥94%

assay

≥99.0% (HPLC)

assay

≥97% (TLC)

assay

≥94%

form

powder

form

powder

form

powder

form

powder

mol wt

micellar avg mol wt 600

mol wt

micellar avg mol wt 600, average mol wt 600

mol wt

micellar avg mol wt 600, average mol wt 600

mol wt

micellar avg mol wt 600, average mol wt 600

General description

Sodium lauroyl sarcosinate, the sodium salt of an acyl derivative of sarcosine—a natural amino acid occurring in muscles and body tissues—stands out as a valuable component in molecular biology, biochemical, and cell biology research. Derived from a natural fatty acid and the amino acid derivative sarcosine, N-Lauroylsarcosine is a biodegradable anionic surfactant usually synthesized through acylation and neutralization reactions involving lauric acid and sodium sarcosine.

This amino acid-type anionic surfactant, also recognized as a fatty acid amide and detergent, exhibits protein denaturant potency and has been integrated into lysing solutions, such as the cornet assay. Its application extends to lysing protoplasts for chromosomal DNA isolation from Streptococcus mutans. Notably, Lauroylsarcosine Sodium Salt, characterized by its ionic detergent properties, is commonly employed for purifying membrane proteins. Additionally, Sodium Lauroyl Sarcosine also plays a crucial role in concentrated salt solutions, facilitating cell lysis in RNA purification protocols and membrane solubilization. Whether it′s breaking down cell structures or facilitating membrane protein purification, this mild surfactant proves valuable in various applications within the realms of biology and biochemistry.

Application

Suitable for
  • solubilization and separation of membrane proteins
  • lysis of cells during the isolation of RNA
  • inhibition of hexokinase

Features and Benefits

  • Suitable for Molecular Biology, Biochemical and Cell Biology research
  • Can be used for Protein Purification and Quantification
  • High purity product for research applications

Other Notes

Anionic surfactant.

Pictograms

CorrosionSkull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 2 Inhalation - Eye Dam. 1 - Skin Irrit. 2

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 1

Flash Point(F)

512.6 °F - closed cup

Flash Point(C)

267 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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