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63559

Sigma-Aldrich

D-Mannitol

BioUltra, ≥99.0% (sum of enantiomers, HPLC)

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Synonym(s):
Mannite
Empirical Formula (Hill Notation):
C6H14O6
CAS Number:
Molecular Weight:
182.17
Beilstein/REAXYS Number:
1721898
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

product line

BioUltra

Quality Level

assay

≥99.0% (sum of enantiomers, HPLC)

form

powder

optical activity

[α]20/D +24.0±1° in borax solution acc. to Ph Eur

impurities

insoluble matter, passes filter test
reducing sugars, complies
≤0.0072% free acid (as CH3COOH)

ign. residue

≤0.01% (as SO4)

loss

≤0.05% loss on drying, 20 °C (HV)

color

white

pH

5.0-6.5 (25 °C, 1 M in H2O)

mp

166-168 °C
167-170 °C (lit.)

solubility

H2O: 1 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤1 mg/kg
Pb: ≤1 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

1 M in H2O

UV absorption

λ: 260 nm Amax: 0.04
λ: 280 nm Amax: 0.04

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

InChI key

FBPFZTCFMRRESA-KVTDHHQDSA-N

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1 of 4

This Item
63560M8429M9647
vibrant-m

63559

D-Mannitol

Premium Grade
vibrant-m

63560

D-Mannitol

-
vibrant-m

M8429

D-Mannitol

-
vibrant-m

M9647

D-Mannitol

Essential Grade
assay

≥99.0% (sum of enantiomers, HPLC)

assay

≥99.0% (sum of enantiomers, HPLC)

assay

≥96.0%

assay

-

solubility

H2O: 1 M at 20 °C, clear, colorless

solubility

H2O: 0.1 g/mL, clear, colorless

solubility

water: soluble 182 g/L at 20 °C (68 °F)

solubility

water: soluble 182 g/L at 20 °C (68 °F)

mp

166-168 °C, 167-170 °C (lit.)

mp

165-169 °C, 167-170 °C (lit.)

mp

167-170 °C (lit.)

mp

167-170 °C (lit.)

product line

BioUltra

product line

-

product line

-

product line

-

impurities

insoluble matter, passes filter test, ≤0.0072% free acid (as CH3COOH), reducing sugars, complies

impurities

-

impurities

<1 ppm Lead

impurities

Reducing sugars, passes test, ≤0.0008 meq/g Titratable acid, ≤0.01% Insoluble matter

Application

D-Mannitol is used as an osmolyte and transport facilitator in a variety of biological in vivo and in vitro applications, such as improvement of blood-brain barrier transport and hyperosmolar therapy. D-Mannitol is used as a substrate to identify, differentiate and characterized enzymes such as mannitol dehydrogenase(s). D-Mannitol is used in identify mannitol metabolizing bacteria.

Biochem/physiol Actions

A sugar alcohol sweet tastant. Used in sweetness inhibition studies.

Other Notes

To gain a comprehensive understanding of our extensive range of Sugar alcohols for your research, we encourage you to visit our Carbohydrates Category page.
Used in discontinuous gradient centrifugation for purification of plant protoplasts. Plasmolyticum that reversibly inhibits phenylalanine ammonia-lyase activity of protoplasts at concentrations exceeding 50 mM. Component of the liquid stationary phase in the GLC separation of nitroxylene and xylenol isomers.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

ppe

Eyeshields, Gloves, type N95 (US)


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Anna Stepanova et al.
Antioxidants & redox signaling, 31(9), 608-622 (2019-05-01)
Aims: Brain ischemia/reperfusion (I/R) is associated with impairment of mitochondrial function. However, the mechanisms of mitochondrial failure are not
B. Fritig
Phytochemistry, 16, 895-895 (1977)
B.G. Hughes
Biochem. Physiol. Pflanz., 172, 223-223 (1978)
Separation behaviour of some isomeric organic compounds on sugars, sugar alcohols and their mixed phases by gas-liquid chromatography.
Ono, A.
Journal of Chromatography A, 197, 251-251 (1980)
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To define whether coughing during mannitol challenge is a nonspecific side effect of this challenge or is associated with asthma. A prospective study. University hospital. Thirty-seven steroid-naive, asthmatic subjects and 10 healthy subjects. The participants completed a symptom questionnaire, recorded

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