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69453

Sigma-Aldrich

L-Homocysteine

≥98.0% (NT)

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Synonym(s):
(S)-2-Amino-4-mercaptobutyric acid
Linear Formula:
HSCH2CH2CH(NH2)COOH
CAS Number:
Molecular Weight:
135.18
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.32

Quality Level

assay

≥98.0% (NT)

form

powder

optical activity

[α]/D 25.5±1.5°, c = 1 in 1 M HCl

color

white

mp

263-265 °C

application(s)

cell analysis

relevant disease(s)

Alzheimer′s disease

storage temp.

−20°C

SMILES string

N[C@@H](CCS)C(O)=O

InChI

1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1

InChI key

FFFHZYDWPBMWHY-VKHMYHEASA-N

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This Item
H4628H6010H6503
vibrant-m

69453

L-Homocysteine

vibrant-m

H4628

DL-Homocysteine

vibrant-m

H6010

L-Homocystine

assay

≥98.0% (NT)

assay

≥95% (titration)

assay

≥98% (HPLC)

assay

≥98% (TLC)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

storage temp.

-

Quality Level

100

Quality Level

200

Quality Level

300

Quality Level

200

mp

263-265 °C

mp

232-233 °C (lit.)

mp

281-284 °C (dec.) (lit.)

mp

185 °C

optical activity

[α]/D 25.5±1.5°, c = 1 in 1 M HCl

optical activity

-

optical activity

-

optical activity

-

General description

L-homocysteine is used to diagnose homocystinuria.

Application

L-homocysteine has been used as a supplement in cell culture media.

Biochem/physiol Actions

Elevated homocysteine levels in plasma and tissue are associated with brain atrophy in Alzheimer′s disease as well as in healthy eldery subjects. Increased homocysteine is due to deficiencies in vitamin B status, specifically folate, B6 and B12 vitamins, which act as cofactors for enzymes involved in homocysteine metabolism.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Customers Also Viewed

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K Mehlig et al.
Heart (British Cardiac Society), 99(23), 1761-1765 (2013-09-10)
An elevated level of total plasma homocysteine (tHcy) has been associated with risk of coronary heart disease (CHD). The level of tHcy is affected by lifestyle, in addition to genetic predisposition. The methylene tetrahydrofolate reductase (MTHFR) 677C>T polymorphism (rs1801133) is
Sanne Visser et al.
American journal of obstetrics and gynecology, 211(4), 373-373 (2014-03-19)
The aim of this study was to investigate which nonclassic cardiovascular biomarkers are associated with persistent endothelial dysfunction after pregnancy in women with a history of hypertensive pregnancy disorders compared with women with uncomplicated pregnancies. This was a systematic review
SAGE open medicine, 286054-286054 (2014)
James J H Chong et al.
Journal of the American Heart Association, 8(1), e011028-e011028 (2019-01-01)
Background Neutrophil gelatinase-associated lipocalin ( NGAL ) or lipocalin 2 may promote atherosclerosis and plaque instability leading to increased risk of cardiac events. We investigated the relationships between plasma NGAL , cardiovascular disease biomarkers, and long-term cardiac events. Methods and
Babak Hooshmand et al.
Brain : a journal of neurology, 136(Pt 9), 2707-2716 (2013-08-29)
Elevated plasma total homocysteine is associated with increased risk of dementia/Alzheimer's disease, but underlying pathophysiological mechanisms are not fully understood. This study investigated possible links between baseline homocysteine, and post-mortem neuropathological and magnetic resonance imaging findings up to 10 years

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