A9650

Angiotensin I human acetate salt hydrate

≥90% (HPLC), powder, suitable for mammalian cell culture

• Synonym(s): 5-Ile-angiotensin I, 5-Isoleucine-angiotensin I, Pepsitensin, Proangiotensin, Hypertensin I
• Empirical Formula (Hill Notation): C₆₂H₈₉N₁₇O₁₄ · xC₂H₄O₂ · yH₂O
• CAS Number: 70937-97-2
• Molecular Weight: 1296.48 (anhydrous free base basis)
• MDL number: MFCD00133091
• UNSPSC Code: 12352202
• eCl@ss: 42020611
• PubChem Substance ID: 24891483
• NACRES: NA.32

Properties

• biological source: human
• Quality Level: 200
• assay: ≥90% (HPLC)
• form: powder
• mol wt: 1296 Da by calculation (Average Mass)
• storage condition: (Keep container tightly closed in a dry and well-ventilated place)
• technique(s): cell culture | mammalian: suitable
• solubility: acetic acid: 25 mg/mL, clear, colorless
• UniProt accession no.: P01019
• storage temp.: −20°C

Description

Amino Acid Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu

General description

Angiotensinogen (Angiotensin I) is a renin substrate, which is produced by the liver.[1]

Research area: Cell Signaling

Application

Angiotensin I human acetate salt hydrate has been used:

• as an external calibration standard, it was applied to α-cyano-4-hydroxycinnamic acid (CHCA) and 2,5-dihydroxybenzoic acid (DHB) matrix[2],
• to prepare angiotensin I solution gravimetrically for hydrolysis and also used as a model peptide to demonstrate SI (système international) -traceable amino acid analysis[3]
• as an analyte to deposit on the target in the study of on-line single droplet deposition for matrix-assisted laser desorption/ionization (MALDI) mass spectrometry[4]

Biochem/physiol Actions

Angiotensin I is a putative neurotransmitter. It is the precursor of angiotensin II and of angiotensin fragment 1-7, which are the hormones involved in regulation of fluid volume and the release of aldosterone.

Angiotensin is a component of the renin-angiotensin aldosterone system (RAAS). This hormonal circulating system[5] aids in regulating blood pressure by modulating potassium secretion, vascular tone, and sodium and water reabsorption. RAAS also participates in fibrosis, apoptosis, and inflammation.[6]

Putative neurotransmitter; precursor of angiotensin II and of angiotensin fragment 1-7.

Antibody Adsorbant

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH.2CH₃COOH.6H₂O

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)