A0788

3-Aminobenzamide

≥99% (TLC)

• Synonym(s): 3-AB, 3-ABA
• Linear Formula: H₂NC₆H₄CONH₂
• CAS Number: 3544-24-9
• Molecular Weight: 136.15
• EC Number: 222-586-9
• MDL number: MFCD00007989
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278206
• NACRES: NA.77

Properties

• assay: ≥99% (TLC)
• form: powder
• color: white to off-white
• mp: 115-116 °C (lit.)
• solubility: ethanol: 50 mg/mL, clear, light yellow; DMSO: soluble; H₂O: soluble (may require gentle heating)
• storage temp.: room temp
• SMILES string: NC(=O)c1cccc(N)c1
• InChI: 1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10)
• InChI key: GSCPDZHWVNUUFI-UHFFFAOYSA-N
• Gene Information: mouse ... Parp1(11545)

Description

Application

3-Aminobenzamide has been used as a poly-(ADP-ribose) polymerase (PARP) inhibitor in various experimental studies.

Biochem/physiol Actions

3-Aminobenzamide enhances cell death, unscheduled DNA synthesis and repair replication by interrupting the rejoining of DNA strand breaks induced by both ionizing radiations and several alkylating agents. It has an ability to inhibit the activity of nuclear enzyme poly (ADP-ribose) synthetase (PARS). 3-Aminobenzamide exhibits protective action against myocardial reperfusion injury and local inflammation.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves