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A2661

Sigma-Aldrich

Acetylcholine chloride

suitable for cell culture

Synonym(s):
ACh
Linear Formula:
(CH3)3N+CH2CH2OCOCH3Cl-
CAS Number:
Molecular Weight:
181.66
Beilstein:
3571875
EC Number:
MDL number:
eCl@ss:
32190102
PubChem Substance ID:
NACRES:
NA.75

biological source

synthetic

Quality Level

Assay

~99%

form

powder

technique(s)

cell culture | mammalian: suitable

mp

146-150 °C (lit.)

solubility

water: 100 mg/mL, clear, colorless

shipped in

ambient

storage temp.

room temp

SMILES string

[Cl-].CC(=O)OCC[N+](C)(C)C

InChI

1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1

InChI key

JUGOREOARAHOCO-UHFFFAOYSA-M

Gene Information

human ... CHRM3(1131)

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Acetylcholine chloride suitable for cell culture

Sigma-Aldrich

A2661

Acetylcholine chloride

Acetylcholine chloride pkg of 150 mg (per vial)

Sigma-Aldrich

A9101

Acetylcholine chloride

Progesterone γ-irradiated, BioXtra, suitable for cell culture

Sigma-Aldrich

P6149

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Hydrocortisone BioReagent, suitable for cell culture

Sigma-Aldrich

H0888

Hydrocortisone

assay

~99%

assay

≥99% (TLC)

assay

≥99%

assay

≥98%

form

powder

form

powder or crystals

form

powder

form

powder

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

mp

146-150 °C (lit.)

mp

146-150 °C (lit.)

mp

128-132 °C (lit.)

mp

211-214 °C (lit.)

solubility

water: 100 mg/mL, clear, colorless

solubility

H2O: soluble

solubility

chloroform: 50 mg/mL, clear, colorless to light yellow

solubility

chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to very faintly yellow

Application

Acetylcholine chloride has been used in the preparation of acetylcholine, that is used as a common vehicle for iontophoresis of acetylcholine (ACh). It has also been used to treat aNS-1 derived neurons for cAMP (cyclic adenosine monophosphate) assay and also used to check their ability to influence G protein-coupled receptors (GPCRs).

Biochem/physiol Actions

Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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25G
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