AV100871
Anti-TCF3 (AB2) antibody produced in rabbit
IgG fraction of antiserum
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Synonym(s):
Anti-E2A, Anti-ITF1, Anti-MGC129647, Anti-MGC129648, Anti-Transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
48 kDa
species reactivity
mouse, dog, guinea pig, human, rat
concentration
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TCF3(6929)
Immunogen
Synthetic peptide directed towards the C terminal region of human TCF3
Application
Anti-TCF3 antibody produced in rabbit is suitable for western blotting at a concentration of 5 μg/ml.
Biochem/physiol Actions
TCF3 belongs to the E-protein (class I) family of transcription factors and is an important regulator of B and T lymphocyte development, tumor growth and progression. TCF3 modulates the Wnt-mediated signaling and regulates osteogenesis and neural differentiation.
Sequence
Synthetic peptide located within the following region: EENTSAADHSEEEKKELKAPRARTSPDEDEDDLLPPEQKAEREKERRVAN
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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W Liu et al.
Cell death & disease, 4, e539-e539 (2013-03-16)
Wnt signaling pathways are a highly conserved pathway, which plays an important role from the embryonic development to bone formation. The effect of Wnt pathway on osteogenesis relies on their cellular environment and the expression of target genes. However, the
Michal Slyper et al.
Cancer research, 72(21), 5613-5624 (2012-10-24)
Regulatory factors controlling stem cell identity and self-renewal are often active in aggressive cancers and are thought to promote their growth and progression. TCF3 (also known as TCF7L1) is a member of the TCF/LEF transcription factor family that is central
Yaser Atlasi et al.
PLoS genetics, 9(5), e1003424-e1003424 (2013-05-10)
Canonical Wnt signaling plays a rate-limiting role in regulating self-renewal and differentiation in mouse embryonic stem cells (ESCs). We have previously shown that mutation in the Apc (adenomatous polyposis coli) tumor suppressor gene constitutively activates Wnt signaling in ESCs and
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