AV31926

Anti-RAX (AB2) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-RX, Anti-Retina and anterior neural fold homeobox
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 37 kDa
• species reactivity: horse, mouse, human, guinea pig, bovine, rat
• concentration: 0.5 mg - 1 mg/mL
• technique(s): immunohistochemistry: suitable; western blot: suitable
• NCBI accession no.: NP_038463
• UniProt accession no.: Q9Y2V3
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... RAX(30062)

Description

General description

Rabbit polyclonal anti-RAX (AB2) antibody reacts with bovine, canine, human, mouse, and rat retina and anterior neural fold homeobox factors.

Retina and anterior neural fold homeobox (RAX) is a paired-type homeobox gene expressed in the anterior neural fold and developing retina. RAX is involved in defining the eye field during early development wherein it participates in regulation of the proliferation and/or differentiation of retinal cells. Defects in RAX have been linked to the eye pathologies microphthalmia and anophthalmia.

Immunogen

Synthetic peptide directed towards the N terminal region of human RAX

Application

Rabbit Anti-RAX (AB2) antibody can be used for western blot assays at a concentration of 0.5μg/ml.

Rabbit polyclonal anti-RAX (AB2) antibody is used to tag retina and anterior neural fold homeobox for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of retina and anterior neural fold homeobox in eye field/retinal development and eye pathologies such as microphthalmia and anophthalmia.

Biochem/physiol Actions

Retinal Homeobox Protein Rx (RAX) is a member of homeobox family of transcription factors. Mutations mouse and fish RAX lead to defects in retinal development and result in animal models of anophthalmia.

Sequence

Synthetic peptide located within the following region: MHLPGCAPAMADGSFSLAGHLLRSPGGSTSRLHSIEAILGFTKDDGILGT

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable