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Key Documents

AV34212

Sigma-Aldrich

Anti-BRD2 (AB1) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-Bromodomain containing 2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

88 kDa

species reactivity

bovine, human, horse, dog, mouse, rat, pig

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_001106653

UniProt accession no.

P25440

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BRD2(6046)

General description

BRD2 encodes a transcription factor that is a bromodomain containing protein. Brd2/RING3 is known to associate with the chromatin binding domain of LANA-1 in KSHV (Kaposi′s sarcoma-associated herpesvirus)-infected cells. BRD2 may also be a susceptibility gene for juvenile myoclonic epilepsy.
Rabbit Anti-BRD2 (AB2) antibody recognizes human, mouse, rat, canine, zebrafish, chicken, bovine, and pig BRD2.

Immunogen

Synthetic peptide directed towards the middle region of human BRD2

Application

Rabbit Anti-BRD2 is suitable for western blot applications at a concentration of 0.5 μg/ml.

Biochem/physiol Actions

BRD2 encodes a mitogen-activated kinase which localizes to the nucleus. BRD2 maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3 but sequence comparison suggests that the protein is not involved in the immune response. Homology to the Drosophila gene female sterile homeotic suggests that this human gene may be part of a signal transduction pathway involved in growth control.

Sequence

Synthetic peptide located within the following region: QEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADEDD

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Deb K Pal et al.
American journal of human genetics, 73(2), 261-270 (2003-06-28)
Juvenile myoclonic epilepsy (JME) is a common form of generalized epilepsy that starts in adolescence. A major JME susceptibility locus (EJM1) was mapped to chromosomal region 6p21 in three independent linkage studies, and association was reported between JME and a
Abel Viejo-Borbolla et al.
Journal of virology, 79(21), 13618-13629 (2005-10-18)
Latency-associated nuclear antigen 1 (LANA-1) of Kaposi's sarcoma-associated herpesvirus (KSHV) mediates the episomal replication of the KSHV genome, as well as transcriptional regulation, in latently infected cells. Interaction of LANA-1 with cellular chromatin is required for both these functions. An

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