AV53850
Anti-ZC3H14 antibody produced in rabbit
affinity isolated antibody
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Synonym(s):
Anti-FLJ11806, Anti-MGC26892, Anti-NY-REN-37, Anti-UKp68, Anti-Zinc finger CCCH-type containing 14
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
35 kDa
species reactivity
human
concentration
0.5 mg - 1 mg/mL
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... ZC3H14(79882)
Immunogen
Synthetic peptide directed towards the N terminal region of human ZC3H14
Application
Anti-ZC3H14 antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL.
Biochem/physiol Actions
ZC3H14 gene encodes a ubiquitously expressed evolutionarily conserved Cys(3)His zinc finger protein that belongs to poly(A)-binding protein family. The encoded protein plays an evolutionarily conserved role in regulating the poly(A) tail length in neurons.Poly(A)-binding proteins also impacts the gene expression by controlling mRNA stability, nuclear export, and translation.Mutation in ZC3H14 gene leads to brain disorder occur due to disrupted normal development and impairs neural function in humans and drosophila.
Sequence
Synthetic peptide located within the following region: KFPSPPLPIFLPPEPVDLGSITSSSCSLNELDNISHLLRKISADINEIKG
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Seth M Kelly et al.
RNA (New York, N.Y.), 20(5), 681-688 (2014-03-29)
The ZC3H14 gene, which encodes a ubiquitously expressed, evolutionarily conserved, nuclear, zinc finger polyadenosine RNA-binding protein, was recently linked to autosomal recessive, nonsyndromic intellectual disability. Although studies have been carried out to examine the function of putative orthologs of ZC3H14
Sara W Leung et al.
Gene, 439(1-2), 71-78 (2009-03-24)
The human ZC3H14 gene encodes an evolutionarily conserved Cys(3)His zinc finger protein that binds specifically to polyadenosine RNA and is thus postulated to modulate post-transcriptional gene expression. Expressed sequence tag (EST) data predicts multiple splice variants of both human and
Changhui Pak et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(30), 12390-12395 (2011-07-08)
Here we report a human intellectual disability disease locus on chromosome 14q31.3 corresponding to mutation of the ZC3H14 gene that encodes a conserved polyadenosine RNA binding protein. We identify ZC3H14 mRNA transcripts in the human central nervous system, and we
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