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C1879

Sigma-Aldrich

Choline chloride

≥98%

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Synonym(s):
(2-Hydroxyethyl)trimethylammonium chloride
Linear Formula:
(CH3)3N(Cl)CH2CH2OH
CAS Number:
Molecular Weight:
139.62
Beilstein:
3563126
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic

Quality Level

Assay

≥98%

form

powder or crystals

technique(s)

cell culture | mammalian: suitable

color

colorless to white

mp

302-305 °C (dec.) (lit.)

SMILES string

[Cl-].C[N+](C)(C)CCO

InChI

1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1

InChI key

SGMZJAMFUVOLNK-UHFFFAOYSA-M

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This Item
C7527C701726978
Choline chloride ≥98%

Sigma-Aldrich

C1879

Choline chloride

-
Choline chloride BioReagent, suitable for cell culture, suitable for insect cell culture, ≥98%

Sigma-Aldrich

C7527

Choline chloride

-
Choline chloride ≥99%

Sigma-Aldrich

C7017

Choline chloride

-
Choline chloride BioUltra, ≥99.0% (AT)

Sigma-Aldrich

26978

Choline chloride

Premium Grade
form

powder or crystals

form

crystals

form

powder

form

powder or crystals

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable, cell culture | plant: suitable

technique(s)

-

technique(s)

-

color

colorless to white

color

white

color

white

color

colorless to white

biological source

synthetic

biological source

synthetic (organic)

biological source

synthetic

biological source

synthetic

mp

302-305 °C (dec.) (lit.)

mp

302-305 °C (dec.) (lit.)

mp

302-305 °C (dec.) (lit.)

mp

302-305 °C (dec.) (lit.)

General description

Choline chloride is the synthetic form of vitamin B4, choline and is a common poultry feed.

Application

Choline chloride has been used:
  • as a substrate for measuring choline oxidase enzyme activity using fluorescence measurements
  • as a component of non-physiological buffers for testing calcium based inhibition of cytochrome c oxidaseP
  • as a component of perfusate solution for studying arterial pressure in jejunum samples

Biochem/physiol Actions

Choline chloride treatment of radish seeds modulates phosphatidylcholine and phosphatidylethanolamine levels. It elicits hepatoprotective effects and modulates methyl carbon based metabolic pathways.
The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes .

Substrates

Choline acetyltransferase substrate

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Rapid enzymatic method for the determination of phosphoryl choline using the fluorescence of the enzyme choline oxidase. Sequential determination of choline and phosphorylcholine in milk powder for children
Sanz-Vicente I, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 123, 259-266 (2015)
Effect of choline chloride on the lipid content and composition in the leaves of principal magnetically-oriented radish types
Novitskaya GV, et al.
Russian Journal of Plant Physiology, 51(3), 361-371 (2004)
Evaluation of polyherbal formulation and synthetic choline chloride on choline deficiency model in broilers: implications on zootechnical parameters, serum biochemistry and liver histopathology
Selvam R, et al.
Asian-Australasian Journal of Animal Sciences, 31(11), 1795-1795 (2018)
Choline and methionine differentially alter methyl carbon metabolism in bovine neonatal hepatocytes
Chandler TL and White HM
PLoS ONE, 12(2), e0171080-e0171080 (2017)
An investigation into the relationship between small intestinal fluid secretion and systemic arterial blood pressure in the anesthetized rat
Lucas ML and Morrison JD
Physiological Reports, 3(5) (2015)

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