C2401

Crotaline

Pulmotoxic, powder

• Synonym(s): (-)-Monocrotaline, Monocrotaline
• Empirical Formula (Hill Notation): C₁₆H₂₃NO₆
• CAS Number: 315-22-0
• Molecular Weight: 325.36
• NACRES: NA.77
• PubChem Substance ID: 24892326
• UNSPSC Code: 12352200
• MDL number: MFCD00084656
• Beilstein/REAXYS Number: 48732
• Form: powder

Properties

• Product Name: Crotaline,
• form: powder
• mp: 204 °C (dec.) (lit.)
• storage temp.: 2-8°C
• SMILES string: [H][C@@]12[C@H]3CCN1CC=C2COC(=O)[C@](C)(O)[C@](C)(O)[C@@H](C)C(=O)O3
• InChI: 1S/C16H23NO6/c1-9-13(18)23-11-5-7-17-6-4-10(12(11)17)8-22-14(19)16(3,21)15(9,2)20/h4,9,11-12,20-21H,5-8H2,1-3H3/t9-,11+,12+,15+,16-/m0/s1
• InChI key: QVCMHGGNRFRMAD-XFGHUUIASA-N

Description

General description

Crotaline is a macrocyclic compound belonging to the pyrrolizidine alkaloid family. It is naturally present in Crotalaria spectabilis.

Application

Crotaline has been used in hydrochloric acid (HCl) and injected into experimental animals to induce-pulmonary hypertension.

Biochem/physiol Actions

Crotaline induces pulmonary vascular syndrome in rats. It is considered toxic and results in hepatic cirrhosis, enlarged liver, sinusoidal obstruction syndrome and right ventricular hypertrophy.Monocrotaline is known to inhibit the growth of various experimental tumors.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Codes: H301,H351
• Precautionary Statements: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Carc. 2
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges