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C3130

Sigma-Aldrich

Cortisone 21-acetate

≥99%

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Synonym(s):
17α,21-Dihydroxy-4-pregnene-3,11,20-trione 21-acetate, 21-Acetoxy-4-pregnen-17α-ol-3,11,20-trione, 4-Pregnene-17α,21-diol-3,11,20-trione 21-acetate
Empirical Formula (Hill Notation):
C23H30O6
CAS Number:
Molecular Weight:
402.48
Beilstein/REAXYS Number:
2067543
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

sterility

non-sterile

assay

≥99%

form

powder

mp

237-240 °C (lit.)

solubility

chloroform: 50 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])C(=O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(C)=O

InChI

1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-17,20,28H,4-9,11-12H2,1-3H3/t16-,17-,20+,21-,22-,23-/m0/s1

InChI key

ITRJWOMZKQRYTA-RFZYENFJSA-N

Gene Information

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1 of 4

This Item
C2755D7000P6254
Cortisone 21-acetate ≥99%

C3130

Cortisone 21-acetate

Cortisone ≥95%

C2755

Cortisone

Deoxycorticosterone acetate

D7000

Deoxycorticosterone acetate

Prednisone ≥98%

P6254

Prednisone

assay

≥99%

assay

≥95%

assay

≥98% (HPLC)

assay

≥98%

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

solubility

chloroform: 50 mg/mL, clear, colorless to faintly yellow

solubility

chloroform: methanol (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow

solubility

H2O: insoluble, acetone: soluble (1 in 30), alcohol: soluble (1 in 50), chloroform: freely soluble, dioxane: slightly soluble, vegetable oils: slightly soluble

solubility

chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to light yellow

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

biological source

synthetic (organic)

biological source

synthetic

biological source

synthetic (organic)

biological source

synthetic

General description

Cortisone 21-acetate is a prodrug, which has glucocorticoid and mineralocorticoid properties. It is used as a therapeutic option for glucocorticoid replacement.

Application

Cortisone 21-acetate has been used to study its effects in metastasis and phagocytic activity.

pictograms

Health hazard

signalword

Warning

hcodes

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Foye's Principles of Medicinal Chemistry (2008)
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