C6019
Clotrimazole
98.5-100.5% (dry basis), powder, Ca²⁺-activated K⁺ channels inhibitor
Recommended Products
form
powder
Quality Level
antibiotic activity spectrum
fungi
mode of action
cell membrane | interferes
protein synthesis | interferes
originator
Schering Plough
SMILES string
Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
InChI
1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChI key
VNFPBHJOKIVQEB-UHFFFAOYSA-N
Gene Information
human ... ABCB1(5243) , CYP17A1(1586) , CYP3A4(1576)
mouse ... Abcb1a(18671) , Abcb1b(18669)
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General description
Application
- to study the upregulation of the gene ERG11 that codes for an azole target enzyme lanosterol demethylase, in Candida species, upon treatment with azole antibiotics
- to study the development of resistance in Candida species isolated from patients undergoing prolonged antifungal treatment
- to induce stress granules via mitochondrial stress
- for the inhibition of in vitro formation of high density sickle cells induced by treatment with 1-chloro-2,4-dinitrobenzene (CDNB)
- to inhibit cytochrome P450 enzyme in cell cultures
Biochem/physiol Actions
Features and Benefits
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
wgk_germany
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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