Skip to Content
MilliporeSigma
All Photos(1)

Documents

C6348

Sigma-Aldrich

Monoclonal Anti-CXCR2 (IL-8 RB) antibody produced in mouse

clone 48311.211, purified immunoglobulin, lyophilized powder

Sign Into View Organizational & Contract Pricing


About This Item

MDL number:
UNSPSC Code:
51111800
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

48311.211, monoclonal

form

lyophilized powder

species reactivity

human

technique(s)

flow cytometry: suitable
neutralization: suitable

isotype

IgG2a

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IL8RB(3579)
mouse ... Il8rb(12765)

Related Categories

General description

The antibody will neutralize human cell surface CXCR-2 mediated-myloperoxidase release from human granulocytes induced by GROα. It will not block myeloperoxidase release induced by IL-8. The antibody reacts with human CXCR-2 transfectant cells and not the parent cell line. The antibody shows no cross-reactivity with CXCR-1.

Immunogen

human CXCR2 transfected NSO mouse myeloma cells.

Biochem/physiol Actions

CXCR2 is a G protein-coupled receptor that binds IL-8 with high affinity. It mediates migration of neutrophils to the sites of inflammation. It also binds CXCL1 and stimulates growth of melanomas.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Preparation Note

Purified using protein G.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Snjezana Zaja-Milatovic et al.
Histology and histopathology, 23(11), 1399-1407 (2008-09-12)
Wound healing requires a complex series of reactions and interactions among cells and their mediators, resulting in an overlapping series of events including coagulation, inflammation, epithelialization, formation of granulation tissue, matrix and scar formation. Cytokines and chemokines promote inflammation, angiogenesis
Michael J Robertson
Journal of leukocyte biology, 71(2), 173-183 (2002-01-31)
Natural killer (NK) cells participate in innate and adaptive immune responses to obligate intracellular pathogens and malignant tumors. Two major NK cell subsets have been identified in humans: CD56(dim) CD16+ and CD56(bright) CD16-. Resting CD56(dim) CD16+ NK cells express CXCR1
Chia-Yuan Hsieh et al.
Journal of immunology (Baltimore, Md. : 1950), 193(7), 3693-3703 (2014-08-31)
IFN-γ mediates chemically induced skin inflammation; however, the mechanism by which IFN-γ-producing cells are recruited to the sites of inflammation remains undefined. Secretion of macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, from damaged cells may promote immune cell recruitment.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service