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C6706

Sigma-Aldrich

Z-Leu-Leu-Norvalinal

≥90% (HPLC), powder

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Synonym(s):
MG115, Z-LLnV
Empirical Formula (Hill Notation):
C25H39N3O5
CAS Number:
Molecular Weight:
461.59
PubChem Substance ID:
NACRES:
NA.32

assay

≥90% (HPLC)

form

powder

color

white

solubility

DMSO: soluble

storage temp.

−20°C

SMILES string

CCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O

InChI

1S/C25H39N3O5/c1-6-10-20(15-29)26-23(30)21(13-17(2)3)27-24(31)22(14-18(4)5)28-25(32)33-16-19-11-8-7-9-12-19/h7-9,11-12,15,17-18,20-22H,6,10,13-14,16H2,1-5H3,(H,26,30)(H,27,31)(H,28,32)/t20-,21-,22-/m0/s1

InChI key

QEJRGURBLQWEOU-FKBYEOEOSA-N

Compare Similar Items

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Show Differences

1 of 4

This Item
C221172517C7206
vibrant-m

C6706

Z-Leu-Leu-Norvalinal

vibrant-m

C2211

Z-Leu-Leu-Leu-al

vibrant-m

72517

Z-Phg-OH

vibrant-m

C7206

Z-Gly-OH

form

powder

form

powder

form

powder

form

powder

color

white

color

white

color

-

color

beige

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

storage temp.

-

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

200

solubility

DMSO: soluble

solubility

DMSO: soluble

solubility

-

solubility

-

Amino Acid Sequence

Z-Leu-Leu-Nva

Biochem/physiol Actions

Potent inhibitor of the 20S proteasome (Ki = 21 nM) and 26S proteasome (Ki = 35 nM). Cells treated with 54 μM N-CBZ-Leu-Leu-Norvalinal showed complete block of the G1/S and metaphase transitions and delayed passage through S-phase. Induces apoptosis in Rat-1 and PC12 cells, perhaps by accumulation of stabilized p53.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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