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C7291

Sigma-Aldrich

Clomipramine hydrochloride

≥98% (HPLC), powder

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Synonym(s):
3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, Anafranil hydrochloride
Empirical Formula (Hill Notation):
C19H23ClN2 · HCl
CAS Number:
Molecular Weight:
351.31
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

H2O: 25 mg/mL
0.1 M HCl: soluble

originator

Novartis

SMILES string

Cl.CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13

InChI

1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H

InChI key

WIMWMKZEIBHDTH-UHFFFAOYSA-N

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This Item
PHR1720ARK2091C-118
Clomipramine hydrochloride ≥98% (HPLC), powder

C7291

Clomipramine hydrochloride

Clomipramine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

PHR1720

Clomipramine hydrochloride

Clomipramine hydrochloride

ARK2091

Clomipramine hydrochloride

Clomipramine hydrochloride solution 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

C-118

Clomipramine hydrochloride solution

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

Quality Level

200

Quality Level

300

Quality Level

600

Quality Level

300

solubility

H2O: 25 mg/mL, 0.1 M HCl: soluble

solubility

-

solubility

-

solubility

-

color

white to off-white

color

-

color

-

color

-

originator

Novartis

originator

-

originator

-

originator

-

General description

Clomipramine hydrochloride is an antiobsessional drug. It has anticholinergic activity in vitro and in vivo. Clomipramine is used to treat obsessive compulsive disorder and panic disorder.

Application

Clomipramine hydrochloride has been used to manipulate serotonin (5-HT) mechanisms. It has also been used to study its role on bone mass.
Clomipramine hydrochloride has been used:
  • to study its effect on human serum albumin using UV-visible, fluorescence and circular dichroism (CD) techniques
  • to block itchy E3 ubiquitin protein ligase (ITCH) ubiquitin transthiolation
  • as a serotonin reuptake inhibitor
  • as a homologous to E6AP C terminus (HECT) E3 ligase inhibitor

Biochem/physiol Actions

Clomipramine hydrochloride (CLP) is a amphiphilic drug, with two benzene rings in its structure. It exhibits anti-depressant property by restoring the equilibrium of certain natural materials in the human being. CLP acts as a potential therapeutic for obsessive compulsive disorder.
Tricyclic antidepressant; inhibits serotonin and norepinephrine transporters.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 1 - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Customers Also Viewed

Slide 1 of 9

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E Gur et al.
The Journal of pharmacology and experimental therapeutics, 288(1), 81-87 (1998-12-23)
Augmentation of tricyclic antidepressant (TCA) treatment with triiodothyronine (T3) has been shown to potentiate the therapeutic effect of TCA drugs in depressed patients. We have attempted to elucidate the mechanism of this potentiation by determining the effects of T3 alone
Influence of antidepressant clomipramine hydrochloride drug on human serum albumin: spectroscopic study
Rub MA, et al.
Journal of Molecular Liquids, 241, 91-98 (2017)
Child and Adolescent Clinical Psychopharmacology (2007)
Effects of short-term clomipramine on anxiety-like behavior, cellular metabolism, and oxidative stress in primary fibroblast cells of male and female rats
Jimenez AG, et al.
Physiological Reports, 6(9), e13615-e13615 (2018)
Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay
Koszela J, et al.
BMC biology, 16(1), 88-88 (2018)

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