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N7261

Sigma-Aldrich

Nortriptyline hydrochloride

≥98% (HPLC), powder

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Synonym(s):
3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine hydrochloride, Desmethylamitriptyline hydrochloride
Empirical Formula (Hill Notation):
C19H21N · HCl
CAS Number:
Molecular Weight:
299.84
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

ethanol: 100 mg/mL
H2O: soluble

originator

Eli Lilly

SMILES string

Cl.CNCC\C=C1\c2ccccc2CCc3ccccc13

InChI

1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H

InChI key

SHAYBENGXDALFF-UHFFFAOYSA-N

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1 of 4

This Item
PHR3216C7291I7379
Nortriptyline hydrochloride ≥98% (HPLC), powder

N7261

Nortriptyline hydrochloride

Nortriptyline Hydrochloride pharmaceutical secondary standard, certified reference material

PHR3216

Nortriptyline Hydrochloride

Clomipramine hydrochloride ≥98% (HPLC), powder

C7291

Clomipramine hydrochloride

Imipramine hydrochloride ≥99% (TLC)

I7379

Imipramine hydrochloride

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

≥99% (TLC)

Quality Level

200

Quality Level

300

Quality Level

-

Quality Level

200

solubility

ethanol: 100 mg/mL, H2O: soluble

solubility

-

solubility

H2O: 25 mg/mL, 0.1 M HCl: soluble

solubility

H2O: 50 mg/mL

originator

Eli Lilly

originator

-

originator

Novartis

originator

Novartis

color

white to off-white

color

-

color

white to off-white

color

white

Biochem/physiol Actions

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (Ki = 3.4 nM) than the serotonin transporter (Ki = 161 nM). 5-HT2 serotonin receptor antagonist.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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