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C8791

Sigma-Aldrich

Monoclonal Anti-Cytokeratin Peptide 14 antibody produced in mouse

clone CKB1, ascites fluid

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Synonym(s):
Anti-CK14, Anti-EBS1, Anti-EBS1A, Anti-EBS1B, Anti-EBS1C, Anti-EBS1D, Anti-EBS3, Anti-EBS4, Anti-K14, Anti-NFJ
MDL number:
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

CKB1, monoclonal

contains

15 mM sodium azide

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (frozen sections): suitable
indirect immunofluorescence: 1:200 using methacarn-fixed, paraffin-embedded human tissue sections

isotype

IgM

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KRT14(3861)

Related Categories

General description

Monoclonal Anti-Cytokeratin Peptide 14 (mouse IgM isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Keratin 14 (KRT14) is expressed in keratinocytes and localized to the basal epidermal layer. The gene is mapped to human chromosome 17q21 and encodes an intermediate filament.

Specificity

The antibody reacts with myoepithelial cells in various organs (parotid, submandibular, mammary, prostate, and sweat glands) as well as with the basal layer of certain squamous epithelium (exocervical, laryngeal epithelium).

Immunogen

human callus keratins.

Application

Monoclonal Anti-Cytokeratin Peptide 14 antibody produced in mouse has been used in indirect immunofluorescence or immunoperoxidase techniques.

Biochem/physiol Actions

Keratin 14 (KRT14) is associated with maintaining cellular stability. Mutation in the KRT14 gene leads to epidermolysis bullosa simplex, a genetic disorder. It is known to promote angiogenesis, cell migration and proliferation in cancer cells.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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