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C9487

Sigma-Aldrich

Monoclonal Anti-Calcitonin Gene-Related Peptide antibody produced in mouse

clone CD8, purified immunoglobulin, buffered aqueous solution

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Synonym(s):
Anti-CGRP
MDL number:
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

CD8, monoclonal

form

buffered aqueous solution

species reactivity

guinea pig, human

technique(s)

immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200-1:1,000 using ovenight incubation at 4 °C and sections that have been protease-digested or processed by high temperature antigen retrieval
indirect immunofluorescence: 1:500 using overnight incubation at 4 °C

isotype

IgG1

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CALCA(796)
rat ... Calca(24241)

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This Item
C7113C8198C1821
Gene Information

human ... CALCA(796)
rat ... Calca(24241)

Gene Information

human ... CALCA(796)
rat ... Calca(24241)

Gene Information

rat ... Calca(24241)

Gene Information

human ... CDH1(999), CDH2(1000), CDH3(1001)
mouse ... Cdh1(12550), Cdh2(12558), Cdh3(12560)
rat ... Cdh1(83502), Cdh2(83501), Cdh3(116777)

biological source

mouse

biological source

mouse

biological source

rabbit

biological source

mouse

species reactivity

guinea pig, human

species reactivity

rat, human, canine

species reactivity

rat

species reactivity

canine, frog, snake, guinea pig, chicken, pig, feline, bovine, rabbit, hamster, Psammomys (sand rat), goat, rat, human, sheep, mouse

antibody form

purified immunoglobulin

antibody form

purified from hybridoma cell culture

antibody form

whole antiserum

antibody form

ascites fluid

clone

CD8, monoclonal

clone

4901, monoclonal

clone

polyclonal

clone

CH-19, monoclonal

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General description

Calcitonin gene-related peptide (CGRP) is a vasodilator that belongs to the calcitonin family of peptides. It is produced by motor neurons of peripheral and central nervous system. There are two forms of CGRP, α and β, which exhibit similar functions. The effects of CGRP are mediated by G-protein coupled receptor heterodimer formed by calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein 1 (RAMP1). Several biological effects of CGRP are observed in nervous, endocrine, immune and cardiovascular systems. Multiple studies have implicated CGRP in the pathophysiology of migraine and antagonists to CGRP are being explored as treatment options
Monoclonal Anti-Calcitonin Gene-Related Peptide (CGRP) recognizes human and guinea pig CGRP. It does not cross react with rat CGRP.

Immunogen

peptide corresponding to the C-terminal of rat α−calcitonin gene-related peptite (CGRP).

Application

Anti-Calcitonin Gene-Related Peptide (CGRP) antibody is suitable for immunohistochemistry at a working antibody dilution of 1:200 to 1:1000 using formalin-fixed, paraffin-embedded sections or cryostat tissue sections. The antibody may be used for immunofluorescence at a working dilution of 1:500.

Physical form

Solution in PBS containing 1% BSA and ≤ 0.1% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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C Juaneda et al.
Trends in pharmacological sciences, 21(11), 432-438 (2000-12-21)
Calcitonin gene-related peptides (alpha and beta isoforms), better known as CGRPalpha and CGRPbeta, were isolated twenty years ago. In fact, these were the first peptides to be characterized using a molecular cloning strategy, which is not the traditional approach of
Udayasankar Arulmani et al.
European journal of pharmacology, 500(1-3), 315-330 (2004-10-07)
Migraine is a common neurological disorder that is associated with an increase in plasma calcitonin gene-related peptide (CGRP) levels. CGRP, a neuropeptide released from activated trigeminal sensory nerves, dilates intracranial blood vessels and transmits vascular nociception. Therefore, it is propounded
Ana Recober et al.
Current opinion in neurology, 22(3), 241-246 (2009-05-13)
This review includes the most relevant and recent studies on the biology of calcitonin gene-related peptide (CGRP) as it pertains to primary headaches and particularly to migraine. Especial attention was given to those published within the last year. The development
T Esfandyari et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 14(10), 1439-1446 (2000-07-06)
The receptor responsible for CGRP-induced ion transport and permeability was examined in tissues from animals treated 7 days previously with trinitrobenzenesulfonic acid to induce colitis or in controls. CGRP caused a concentration-dependent increase in short circuit current (I(sc), EC(50) 21
P-C Fan et al.
Cephalalgia : an international journal of headache, 29(8), 883-890 (2009-02-25)
To investigate the role of plasma calcitonin gene-related peptide (CGRP) in paediatric migraine, we prospectively collected 134 blood samples during or between attacks from 66 migraine, 33 non-migraine headache (non-migraine) and 22 non-headache patients, aged 4-18 years. Plasma CGRP concentrations

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