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D5942

Sigma-Aldrich

DAPT

≥98% (HPLC), solid

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Synonym(s):
GSI-IX, LY-374973, N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester
Empirical Formula (Hill Notation):
C23H26F2N2O4
CAS Number:
Molecular Weight:
432.46
MDL number:
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: ~18 mg/mL

originator

Eli Lilly

storage temp.

2-8°C

SMILES string

C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@@H](C(=O)OC(C)(C)C)c2ccccc2

InChI

1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20+/m0/s1

InChI key

DWJXYEABWRJFSP-VBKZILBWSA-N

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1 of 4

This Item
565770E1904M9440
vibrant-m

D5942

DAPT

vibrant-m

565770

γ-Secretase Inhibitor IX

vibrant-m

E1904

Ethyl-3,4-dephostatin

vibrant-m

M9440

Methyl-3,4-dephostatin

form

solid

form

lyophilized

form

solid

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

>99% (HPLC)

assay

>98% (HPLC)

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

originator

Eli Lilly

originator

-

originator

-

originator

-

color

white

color

-

color

brown

color

red-brown

Biochem/physiol Actions

DAPT is a γ-secretase inhibitor and indirectly an inhibitor of Notch, a γ-secretase substrate. Other γ-secretase substrates include LDL receptor-related protein, E-cadherin and ErbB-4. As an inhibitor of γ-secretase, DAPT may be useful in the study of β-amyloid (Aβ) formation. DAPT has been shown to inhibit Notch signaling in studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus (SLE), as well as in cancer cell growth, angiogenesis, and differentiation of human induced pluripotent stem cells (hIPSC).

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.

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