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565750

Sigma-Aldrich

γ-Secretase Inhibitor I

The γ-Secretase Inhibitor I controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

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Synonym(s):
γ-Secretase Inhibitor I, Z-LLNle-CHO
Empirical Formula (Hill Notation):
C26H41N3O5
Molecular Weight:
475.62

Quality Level

assay

≥90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

DMSO: 10 mg/mL
50% acetic acid: soluble

shipped in

ambient

storage temp.

−20°C

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565773565761565749
γ-Secretase Inhibitor I The γ-Secretase Inhibitor I controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

565750

γ-Secretase Inhibitor I

γ-Secretase Inhibitor XII The γ-Secretase Inhibitor XII controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

565773

γ-Secretase Inhibitor XII

Sigma-Aldrich

565761

γ-Secretase Inhibitor IV

β-Secretase Inhibitor II The β-Secretase Inhibitor II, also referenced under CAS 263563-09-3, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

565749

β-Secretase Inhibitor II

assay

≥90% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

General description

Cell permeable. Inhibits γ-secretase, a protease that cleaves the Amyloid Precursor Protein (APP) to generate β-amyloid protein. Inhibition of this enzyme is believed to aid in the prevention of Alzheimer’s disease.
Inhibits γ-secretase, a protease that cleaves the amyloid precursor protein (APP). Inhibition of this enzyme is believed to aid in the prevention of Alzheimer′s disease.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
γ-secretase
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Leu-Leu-Nle-CHO (Nle = Norleucine)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Skovronsky, D.M., et al. 2000. Biochemistry 39, 810.
Hartmann, T., et al. 1997. Nat. Med. 3, 1016.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Shreoshi Sengupta et al.
eLife, 11 (2022-06-02)
Cancer stem cells (CSCs) alone can initiate and maintain tumors, but the function of non-cancer stem cells (non-CSCs) that form the tumor bulk remains poorly understood. Proteomic analysis showed a higher abundance of the extracellular matrix small leucine-rich proteoglycan fibromodulin

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