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PLA0230

Sigma-Aldrich

Rabbit anti-Beta-catenin Antibody, Affinity Purified

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Synonym(s):
88kDa, CTNNB, MRD19, armadillo, beta 1, beta 1 (88kD), beta-catenin, catenin (cadherin-associated protein)

biological source

rabbit

Quality Level

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

Powered by Bethyl Laboratories, Inc.

species reactivity

human, mouse

technique(s)

ChIP: 4-30 μg
immunohistochemistry: 1:100- 1:500
immunoprecipitation (IP): 2- 5 μg/mg
western blot: 1:2,000- 1:10,000

accession no.

NP_001895.1

application(s)

research pathology

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

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SAB4500543SAB4500541SAB4500546
species reactivity

human, mouse

species reactivity

rat, mouse, human

species reactivity

rat, mouse, human

species reactivity

mouse, human, rat

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

technique(s)

ChIP: 4-30 μg, immunoprecipitation (IP): 2- 5 μg/mg, immunohistochemistry: 1:100- 1:500, western blot: 1:2,000- 1:10,000

technique(s)

ELISA: 1:20000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000

technique(s)

ELISA: 1:40000, immunofluorescence: 1:100-1:500, western blot: 1:500-1:1000

technique(s)

ELISA: 1:10000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000

Gene Information

rabbit ... Beta-catenin(1499)

Gene Information

human ... CTNNB1(1499)

Gene Information

human ... CTNNB1(1499)

Gene Information

human ... CTNNB1(1499)

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

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Immunogen

The epitope recognized by PLA0230 maps to a region between residue 760 and 781 of human beta-catenin using the numbering given in entry NP_001895.1 (GeneID 1499).

Physical form

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

Other Notes

Beta-catenin plays an integral role in the Wnt signaling pathway and is critical to morphogenic signaling and body axis specification. Beta-catenin exists in complexes with cadherins, transmembrane proteins that mediate cell adhesion. When Wnt-signaling proteins bind their receptors, beta-catenin is stabilized and accumulates in the cell. Translocation of stabilized beta-catenin allows its association with transcription factors and the activation of specific gene expression.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable


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Andrew J Aman et al.
eLife, 7 (2018-07-18)
Understanding how patterning influences cell behaviors to generate three dimensional morphologies is a central goal of developmental biology. Additionally, comparing these regulatory mechanisms among morphologically diverse tissues allows for rigorous testing of evolutionary hypotheses. Zebrafish skin is endowed with a
Xiaoming Zhang et al.
Molecular therapy. Nucleic acids, 34, 102081-102081 (2023-12-19)
MicroRNAs (miRNAs) control the expression of diverse subsets of target mRNAs, and studies have found miRNA dysregulation in failing hearts. Expression of miR-29 is abundant in heart, increases with aging, and is altered in cardiomyopathies. Prior studies demonstrate that miR-29
Naushad Ali et al.
Scientific reports, 10(1), 10578-10578 (2020-07-01)
Chronic liver injury is a risk factor for cirrhosis and hepatocellular carcinoma (HCC). The molecular mechanisms that regulate the decision between normal injury repair and neoplastic initiation are unclear. Doublecortin-like kinase 1 (DCLK1), a tumor stem cell marker, is induced
Colleen S Stein et al.
Cell reports, 23(13), 3710-3720 (2018-06-28)
Mitochondria are composed of many small proteins that control protein synthesis, complex assembly, metabolism, and ion and reactive oxygen species (ROS) handling. We show that a skeletal muscle- and heart-enriched long non-coding RNA, LINC00116, encodes a highly conserved 56-amino-acid microprotein that we
Elsenoor J Klaver et al.
JCI insight, 6(24) (2021-11-17)
The genetic bases for the congenital disorders of glycosylation (CDG) continue to expand, but how glycosylation defects cause patient phenotypes remains largely unknown. Here, we combined developmental phenotyping and biochemical studies in a potentially new zebrafish model (pmm2sa10150) of PMM2-CDG

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