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SML1581

Sigma-Aldrich

Moxifloxacin hydrochloride

≥98% (HPLC)

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Synonym(s):
12-8039, Avalox, BAY12-8039, 1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydropyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
Empirical Formula (Hill Notation):
C21H24FN3O4· HCl
CAS Number:
Molecular Weight:
437.89
Beilstein/REAXYS Number:
8377447
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -119 to -139°, c = 0.5 in water

storage condition

desiccated

color

white to beige

solubility

H2O: 5 mg/mL, clear (warmed)

storage temp.

−20°C

SMILES string

Cl.COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc4C(=O)C(=CN(C5CC5)c14)C(O)=O

InChI

1S/C21H24FN3O4.ClH/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24;/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28);1H/t11-,16+;/m0./s1

InChI key

IDIIJJHBXUESQI-DFIJPDEKSA-N

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1 of 4

This Item
PHR1542324771448606
vibrant-m

SML1581

Moxifloxacin hydrochloride

vibrant-m

PHR1542

Moxifloxacin Hydrochloride

vibrant-m

32477

Moxifloxacin hydrochloride

vibrant-m

1448606

Moxifloxacin hydrochloride

form

powder

form

-

form

-

form

-

Quality Level

100

Quality Level

300

Quality Level

100

Quality Level

-

solubility

H2O: 5 mg/mL, clear (warmed)

solubility

-

solubility

-

solubility

-

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

color

white to beige

color

-

color

-

color

-

General description

Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial. Moxifloxacin is a 8-methoxy quinolone and differs from other quinolones.

Application

Moxifloxacin hydrochloride has been used to study its antibacterial action against bacteria that have grown to high density.

Biochem/physiol Actions

Moxifloxacin has proved to be effective in treating sinusitis, community-acquired respiratory tract infection, pneumonia and acute exacerbations of chronic bronchitis. It has improved anti-gram positive activity compared to other fluoroquinolone such as ciprofloxacin and ofloxacin. Moxifloxacin is useful in treating skin infections that is of bacterial origin. It is known to have proper penetration into peripheral tissues and inflammatory fluids. Fluoroquinolones stabilize DNA strand breaks created by DNA gyrase and topoisomerase IV by binding to the enzyme-DNA complex. Compared to mammalian DNA gyrase, moxifloxacin has 100 times higher affinity for bacterial DNA gyrase. Moxifloxacin is an antibiotic and works against both Gram-positive and Gram-negative bacteria. Moxifloxacin is being investigated for the treatment of multidrug-resistant tuberculosis.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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An HPLC Method for the Determination of Moxifloxacin in Breast Milk by Fluorimetric Detection with Precolumn Derivatization.
Tekkeli SEK
Acta Chromatographica , 10-10 (2016)
Understanding and sensitizing density-dependent persistence to quinolone antibiotics.
Gutierrez A, et al.
Molecular Cell, 68(6), 1147-1154 (2017)
Ana Topete et al.
Journal of controlled release : official journal of the Controlled Release Society, 326, 245-255 (2020-07-20)
Posterior capsule opacification (PCO) still remains the most frequent long term complication after cataract surgery, while endophthalmitis is rare but severe and should be prevented at all cost. Intraocular lenses (IOLs) with different designs (eg. edge and body-haptics angle) and
R C Walker et al.
Mayo Clinic proceedings, 66(12), 1249-1259 (1991-12-01)
The fluoroquinolone class of antibiotics promises to become as diverse and as important as beta-lactam agents. The fluoroquinolones inhibit bacterial DNA gyrase and are bactericidal. All fluoroquinolones have potent activity against most gram-negative bacteria; ciprofloxacin is the most active against
Structural identification and characterization of impurities in moxifloxacin.
Kumar Y R, et al.
Journal of Pharmaceutical and Biomedical Analysis, 34(5), 1125-1129 (2004)

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