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D6694

Sigma-Aldrich

Anti-DSCR1 (C-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

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Synonym(s):
Anti-ADAP78, Anti-Calcipressin 1, Anti-DSC1, Anti-Down Syndrome Candidate Region 1, Anti-MCIP1, Anti-Myocyte-enriched calcineurin-interacting protein 1, Anti-RCAN1, Anti-RCN1, Anti-Regulator of calcineurin 1
NACRES:
NA.44

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~26 kDa

species reactivity

mouse, rat, human

concentration

~1.5 mg/mL

technique(s)

western blot: 2-4 μg/mL using HEK-293T cells expressing human DSCR1

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RCAN1(1827)
mouse ... Dscr1(54720)
rat ... Dscr1(266766)

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This Item
SAB1300772SAB1300775SAB1405729
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody form

IgG fraction of antiserum

antibody form

IgG fraction of antiserum

antibody form

purified immunoglobulin

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

mol wt

antigen ~26 kDa

mol wt

-

mol wt

-

mol wt

antigen ~13.3 kDa

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General description

DSCR1 (Down Syndrome Candidate Region 1 is encoded by a gene mapped to human chromosome 21q22.1. DSCR1 belongs to a family of conserved proteins named regulators of calcineurin (RCAN), that in humans include RCAN, encoded by the DSCR1L1-2 genes. DSCR1 is highly expressed in the central nervous system (CNS) during early embryonic development, in heart, and in skeletal muscle.

Specificity

Anti-DSCR1 (C-terminal) antibody is specific for DSCR1 in rats, mice and humans. The immunizing peptide specifically inhibits the staining of DSCR1 by immunoblotting.

Immunogen

Synthetic peptide corresponding to a sequence at C-terminal of human DSCR1, conjugated to KLH. This sequence is identical in human DSCR1 isoforms a and b, and rat and mouse DSCR1.

Application

Anti-DSCR1 (C-terminal) antibody is suitable for use in western blot (2-4 μg/mL using HEK-293T cells expressing human DSCR1) and in immunoblotting (approx. 26 kDa).
Anti-DSCR1 (C-terminal) antibody produced in rabbit has been used in proximity ligation assay (PLA) and immunoblotting.

Biochem/physiol Actions

Down Syndrome Candidate Region 1 (DSCR1) is involved in cellular adaptation to oxidative stress, and interacts with calcineurin to inhibit its phosphatase activity, thereby regulating the calcineurin- Nuclear factor of activated T-cells (NFAT) signaling pathway and affecting central nervous system (CNS) development and angiogenesis. Chronic overexpression of DSCR1 has been implicated in additional pathological conditions including Alzheimer′s disease and cardiac hypertrophy, possibly through inhibition of calcineurin activity. DSCR1 is induced by vascular endothelial growth factor (VEGF) in activated endothelial cells and regulates the expression of inflammatory marker genes such as interleukin-8 (IL-8), tissue factor, E-selectin and cyclooxygenase (Cox-2).
Down Syndrome Candidate Region 1 or DSCR1 is a candidate gene involved in the pathogenesis of Down′s Syndrome (DS). DSCR1 is usually expressed in cardiac, skeletal and brain tissues, whereas its overexpression in fetal brain tissues is associated with DS. DSCR1 inhibits calcineurin-mediated mRNA synthesis.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)
Strippoli P, et al.
Genomics, 64(3), 252-263 (2000)
Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells
Hesser BA, et al.
Blood, 104(1), 149-158 (2004)
Xiaoding Wang et al.
Cell death and differentiation, 25(12), 2181-2194 (2018-04-19)
Secretory and transmembrane proteins rely on proper function of the secretory pathway for folding, posttranslational modification, assembly, and secretion. Accumulation of misfolded proteins in the endoplasmic reticulum (ER) stimulates the unfolded protein response (UPR), which communicates between the ER and
RCAN1. 4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells
Alghanem AF, et al.
Angiogenesis, 20(3), 341-358 (2017)
Glucose-regulated protein 78 is essential for cardiac myocyte survival
Wang X, et al.
Cell Death and Differentiation, 25(12), 2181-2181 (2018)

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