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MilliporeSigma
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Key Documents

D9069

Sigma-Aldrich

N-Desmethyltamoxifen HCl

≥98% (HPLC), solid

Synonym(s):

(Z)-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N-methylethylamine, ICI 55,548

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About This Item

Empirical Formula (Hill Notation):
C25H27NO·HCl
CAS Number:
Molecular Weight:
393.95
MDL number:
UNSPSC Code:
12352203
PubChem Substance ID:
NACRES:
NA.77

sterility

non-sterile

Quality Level

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

technique(s)

inhibition assay: suitable

solubility

DMSO: ≥20 mg/mL

shipped in

ambient

storage temp.

room temp

SMILES string

Cl.CC\C(c1ccccc1)=C(/c2ccccc2)c3ccc(OCCNC)cc3

Application

N-Desmethyltamoxifen HCl has been used as an internal standard in high-performance liquid chromatography (HPLC) for the quantification of metabolites from NG2 cell-derived astrocytes.[1]

Biochem/physiol Actions

N-Desmethyltamoxifen HCl is the primary metabolite of tamoxifen. N-Desmethyltamoxifen HCl is an estrogen response modifer and protein kinase C inhibitor.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Health hazardEnvironment

signalword

Danger

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves, type P2 (EN 143) respirator cartridges


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    Injury type-dependent differentiation of NG2 glia into heterogeneous astrocytes
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    Experimental Neurobiology, 308, 72-79 (2018)
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    Voltage-gated sodium channels are targets for many analgesic and antiepileptic drugs whose therapeutic mechanisms and binding sites have been well characterized. We describe the identification of a previously unidentified receptor site within the NavMs voltage-gated sodium channel. Tamoxifen, an estrogen

    Articles

    Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.

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    Chromatograms

    application for HPLC

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