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F1177

Sigma-Aldrich

Fluorescein hyaluronic acid

>95%, powder

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MDL number:
NACRES:
NA.25

Quality Level

assay

>95%

form

powder

mol wt

~800,000 Da

color

orange

solubility

H2O: soluble 1 mg/mL

storage temp.

2-8°C

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FD2000SSML1750F7250
Sigma-Aldrich

F1177

Fluorescein hyaluronic acid

Fidaxomicin ≥95% (HPLC)

SML1750

Fidaxomicin

Fluorescein isothiocyanate isomer I suitable for protein labeling, ≥90% (HPLC), powder

F7250

Fluorescein isothiocyanate isomer I

form

powder

form

powder

form

powder

form

powder

solubility

H2O: soluble 1 mg/mL

solubility

H2O: soluble 25 mg/mL

solubility

DMSO: soluble 1 mg/mL, chloroform: soluble 10 mg/mL, methanol: soluble 10 mg/mL

solubility

acetone: 1 mg/mL

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

assay

>95%

assay

-

assay

≥95% (HPLC)

assay

≥90% (HPLC)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Application

Fluorescein hyaluronic acid has been used in the fluorescence imaging of hyaluronic acid (HA) and dextran surface coated filmsand patterned surfaces. It has also been used in confocal fluorescence microscopy to localize hyaluronic acid in collagen/HA composite gels .

Biochem/physiol Actions

Hyaluronan macromolecules (HAs) coupled to fluorescein amine is exploited to screen the hyaluronidase activity using fluorescence correlation spectroscopy (FCS) by measuring the quenching of fluorescein-labeled HA fragments. It binds on cell surface of malignant mesothelioma derived from human tumors.
Used to bind on cell surface of malignant mesothelioma derived from human tumors.

Other Notes

From cock′s comb or by fermentation.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Rheology and confocal reflectance microscopy as probes of mechanical properties and structure during collagen and collagen/hyaluronan self-assembly
Yang Yl and Kaufman LJ
Biophysical Journal, 96(4), 1566-1585 (2009)
Hyaluronan and dextran modified tubes resist cellular activation with blood contact
Eckmann DM, et al.
Colloids and Surfaces. B, Biointerfaces, 108, 44-51 (2013)
Human macrophage adhesion on polysaccharide patterned surfaces
Tsai IY, et al.
Soft Matter, 7(7), 3599-3606 (2011)
Rafal Fudala et al.
Journal of photochemistry and photobiology. B, Biology, 106, 69-73 (2011-11-16)
In this report we propose a lifetime-based sensing (LBS) for the detection of hyaluronidase (HA-ase). First, we heavily label hyaluronan macromolecules (HAs) with fluorescein amine. The fluorescein labeled HA (HA-Fl) has a weak fluorescence and short fluorescence lifetime due to
Hyaluronan receptors are expressed on human malignant mesothelioma cells but not on normal mesothelial cells
Asplund T and Heldin P
Cancer research, 54(16), 4516-4523 (1994)

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