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F5631

Sigma-Aldrich

Fucoidan from Fucus vesiculosus

Crude

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Synonym(s):
Fucoidin
CAS Number:
MDL number:
NACRES:
NA.25

biological source

algae (Fucus Vesiculosus)

Quality Level

form

powder

quality

Crude

color

light yellow to brown

solubility

H2O: 10 mg/mL, clear to hazy, faintly yellow to brownish-yellow

cation traces

Ca: ≤1%
Na: ≤ 8% (ICP)

storage temp.

room temp

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This Item
F8315F8190F8065
form

powder

form

powder

form

powder

form

powder

color

light yellow to brown

color

white to off-white

color

light yellow

color

white to brown

solubility

H2O: 10 mg/mL, clear to hazy, faintly yellow to brownish-yellow

solubility

water: 10 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

water: 10 mg/mL, clear, colorless to faintly yellow

solubility

water: 10 mg/mL, clear to hazy, colorless to very faintly brown

cation traces

Ca: ≤1%, Na: ≤ 8% (ICP)

cation traces

-

cation traces

-

cation traces

-

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

General description

Fucoidan is a fucose-rich, sulfated polysaccharide isolated from several species of brown seaweed.

Application

Fucoidan from Fucus vesiculosus may be used as a biological response modifier and as a potential therapeutic agent with a wide range of biological activities. It may be used to study its pharmacokinetics, safety, efficacy and methods of delivery as a potential anticancer, anti-immune and anti-inflammatory agent. Fucoidan may be used to assess its potential and formulations for tissue engineering applications.

Biochem/physiol Actions

Studies of fucoidan have found it to have a broad variety of biological activities including antitumor and antiangogenic activities, immunomodulatory, anti-inflammatory, anticoagulant, antithrombotic, and antioxidant activities. Fucoidan induces macrophage activation with subsequently activates mitogen activated protein kinases (MAPKs) and results in natural killer cell proliferation. Fucoidan acts as a nonselective selectin blocker and has been shown to induce apoptosis and suppress angiogenesis.

Preparation Note

Prepared by a modification of the method of Black, W.A.P., et al., J. Sci. Food Agri., 3, 122 (1952).

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Wiktoria Blaszczak et al.
Molecules (Basel, Switzerland), 23(12) (2018-12-14)
Fucoidans have been reported to exert anticancer effects with simultaneous low toxicity against healthy tissue. That correlation was observed in several cancer models, however, it has never been investigated in head and neck cancer before. To magnify the efficacy of
Celina Maria P Guerra Dore et al.
Carbohydrate polymers, 91(1), 467-475 (2012-10-10)
Fucan (SV1) sulfated polysaccharides from the brown algae Sargassum vulgare were extracted, fractionated in acetone and examined with respect to chemical composition, anticoagulant, anti-inflammatory, antithrombotic effects and cellular proliferation. These polysaccharides contain low levels of protein, high level of carbohydrate
Suwaree Kitikiew et al.
Fish & shellfish immunology, 34(1), 280-290 (2012-12-04)
In this study, we examined the effect of fucoidan on the immune response of white shrimp Litopenaeus vannamei and its resistance against Vibrio alginolyticus infection. Fucoidan induced degranulation, caused changes in the cell morphology, and increased activation of prophenoloxidase (proPO)
Jean-Marc Alsac et al.
Journal of vascular surgery, 57(3), 796-805 (2012-11-13)
Neutrophils have been shown to be involved in all stages of human and experimental abdominal aortic aneurysm (AAA) development. The initial processes of neutrophil rolling and trapping in the intraluminal thrombus (ILT) are mediated mainly by P-selectin expressed by activated
Wei Wang et al.
Marine drugs, 10(12), 2795-2816 (2012-12-14)
Recently, the studies on the antiviral activities of marine natural products, especially marine polysaccharides, are attracting more and more attention all over the world. Marine-derived polysaccharides and their lower molecular weight oligosaccharide derivatives have been shown to possess a variety

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