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D6001

Sigma-Aldrich

Dextran sulfate sodium salt from Leuconostoc spp.

average mol wt >500,000 (dextran starting material), contains 0.5-2.0% phosphate buffer, pH 6-8

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CAS Number:
MDL number:
NACRES:
NA.21

biological source

bacterial (Leuconostoc mesenteroides)

Quality Level

form

powder

optical activity

[α]/D 90 to 105 °, c = 6% (w/v) in water

mol wt

average mol wt >500,000 (dextran starting material)

contains

0.5-2.0% phosphate buffer, pH 6-8

composition

Sulfur Content, 16.0-19.0%

color

white to off-white

useful pH range

6.0-8.0 (1% in water)

solubility

H2O: 100 mg/mL

storage temp.

2-8°C

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This Item
D6924D8906D4911
form

powder

form

powder

form

powder

form

powder

color

white to off-white

color

white to off-white

color

off-white

color

white to light yellow

useful pH range

6.0-8.0 (1% in water)

useful pH range

5.5 - 8.0

useful pH range

6.0-8 (10 g/L)

useful pH range

6.0-8 (10 g/L)

solubility

H2O: 100 mg/mL

solubility

H2O: 100 mg/mL

solubility

H2O: 100 mg/mL

solubility

H2O: 100 mg/mL

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

storage temp.

room temp

General description

Dextran sulfate is a negatively charged sulfated polysaccharide, which is produced by the esterification of dextran with chlorosulphonic acid. It has antiviral, anticoagulant and adjuvant properties. Dextran is used to treat hemorrhage, burns, surgery and trauma. It enhances blood flow and blocks erythrocyte aggregation. Dextran decreases the risk of thrombosis and postoperative pulmonary emboli. It acts as a ribonuclease inhibitor.

Application

Dextran sulfate sodium salt Leuconostoc spp has been used:
  • to delipidate fatty plasma(67)(70)
  • to induce inflammatory and carcinogenic response in the distal colon of rodents(68)
  • for the preparation of 3,4-ethylenedioxythiophene (EDOT)(69)

Other Notes

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Zora Djuric et al.
The Journal of nutritional biochemistry, 46, 90-99 (2017-05-10)
Dietary fish oils have potential for prevention of colon cancer, and yet the mechanisms of action in normal and tumor colon tissues are not well defined. Here we evaluated the impact of the colonic fatty acid milieu on the formation
The Molecular Biology of Poliovirus (2012)
Seda Onder et al.
Frontiers in pharmacology, 8, 713-713 (2017-10-27)
Hupresin is a new affinity resin that binds butyrylcholinesterase (BChE) in human plasma and acetylcholinesterase (AChE) solubilized from red blood cells (RBC). Hupresin is available from the CHEMFORASE company. BChE in human plasma binds to Hupresin and is released with
Julien Charest et al.
Developmental cell, 55(4), 483-499 (2020-10-02)
Combinatorial action of transcription factors (TFs) with partially overlapping expression is a widespread strategy to generate novel gene-expression patterns and, thus, cellular diversity. Known mechanisms underlying combinatorial activity require co-expression of TFs within the same cell. Here, we describe the
Delipidation of plasma has minimal effects on human butyrylcholinesterase
Onder S, et al.
Frontiers in Pharmacology, 9, 117-117 (2018)

Protocols

Dextran Sulfate

Dextran sulfates are supplied as the sodium salt forms, making them soluble and stable in water. Dextran sulfate contains approximately 17% sulfur which is equivalent to approximately 2.3 sulfate groups per glucosyl residue.

Related Content

Dextran and Related Polysaccharides

Learn about C6H10O6 or dextran formation, classes and naming. Dextrans are polysaccharides with molecular weights ≥1,000 Dalton, which have a linear backbone of α-linked d-glucopyranosyl repeating units.

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