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G1501

Sigma-Aldrich

L-Glutamic acid potassium salt monohydrate

≥99% (HPLC), powder

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Synonym(s):
MPG, Monopotassium glutamate, Potassium 2-amino-5-hydroxy-5-oxopentanoate, (S)-2-Aminopentanedioic acid, L-α-Aminoglutaric acid potassium salt, L-2-Aminopentanedioic acid potassium salt, Glu, Potassium L-glutamate
Empirical Formula (Hill Notation):
C5H8KNO4 · H2O
CAS Number:
Molecular Weight:
203.23
Beilstein/REAXYS Number:
3637377
MDL number:
PubChem Substance ID:
NACRES:
NA.32

Quality Level

assay

≥99% (HPLC)

form

powder

color

white

SMILES string

O.[K+].N[C@@H](CCC([O-])=O)C(O)=O

InChI

1S/C5H9NO4.K.H2O/c6-3(5(9)10)1-2-4(7)8;;/h3H,1-2,6H2,(H,7,8)(H,9,10);;1H2/q;+1;/p-1/t3-;;/m0../s1

InChI key

XIBUKSQTWSKJMQ-QTNFYWBSSA-M

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1 of 4

This Item
G2128C104M216
vibrant-m

G2128

L-Glutamic acid hydrochloride

vibrant-m

C104

(±)-CPP

vibrant-m

M216

MDL 105,519

assay

≥99% (HPLC)

assay

≥99% (HPLC)

assay

-

assay

≥98% (HPLC)

Gene Information

human ... GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444), GRINA(2907)
mouse ... GRIK1(14805), GRIK2(14806), GRIK3(14807), GRIK4(110637), GRIN1(14810), GRIN2A(14811), GRIN2B(14812), GRIN2C(14813), GRIN2D(14814), GRIN3A(242443), GRIN3B(170483), GRINA(66168)
rat ... GRIK1(29559), GRIK2(54257), GRIK3(298521), GRIK4(24406), GRIN1(24408), GRIN2A(24409), GRIN2B(24410), GRIN2C(24411), GRIN2D(24412), GRIN3A(191573), GRIN3B(170796), GRINA(266668)

Gene Information

human ... GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIK5(2901)

Gene Information

human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)
rat ... Grin2a(24409)

Gene Information

human ... GRIN1(2902)
rat ... Grin1(24408)

form

powder

form

-

form

solid

form

solid

color

white

color

-

color

white

color

white to off-white

General description

L-glutamate is the major excitatory neurotransmitter in mammalian central nervous system (CNS). It interacts with membrane bound glutamate receptors. Potassium -glutamate is also used as a component of MEM non-essential amino acids solution in cell culture.

Application

L-Glutamic acid potassium salt monohydrate has been used-
  • A component of MEM non-essential amino acids solution in cell culture.
  • For the purification of tubulins from bovine brain.
  • In stock solution for the preparation of quenching buffer during the formationof dual-color polarity-marked fluorescent microtubule seeds.
  • The preparation of cell free extracts devoid of RF2 (release factor 2) from Escherichia coli strains.
  • preparation of stock solutions during culture of Arabidopsis plants.

Biochem/physiol Actions

L-glutamate plays key roles in development, learning, memory, plasticity and cognition. It plays crucial role in the pathogenesis of neuropathological diseases such as epilepsy, schizophrenia, stroke, ischemia, ALS (amyotrophic lateral sclerosis), Huntington′s disease and Parkinson′s disease. Glutamate is also responsible for the activation of long-term potentiation (LTP) and long-term depression (LTD). Induction of glutamate receptors plays a key role in the pathophysiology of migraine.
Agonist at kainate, NMDA, and quisqualate receptors; an excitatory amino acid neurotransmitter.

Features and Benefits

Our highly purified L-Glutamic acid potassium salt monohydrate will support your purification or preparation neuropathological diseases research needs

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Customers Also Viewed

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Miho Katsuki et al.
Methods in molecular biology (Clifton, N.J.), 777, 117-126 (2011-07-21)
Assaying microtubule dynamics in vitro requires stabilized nucleation centers, a method to immobilize individual microtubules onto a surface, and a specialized microscope to image the microtubule. Microtubules are polar structures with different dynamic properties at the plus and minus ends.
E D Brenner et al.
Plant physiology, 124(4), 1615-1624 (2000-12-15)
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are the predominant neuroreceptors in the mammalian brain. Genes with high sequence similarity to animal iGluRs have been identified in Arabidopsis. To understand the role of Arabidopsis glutamate receptor-like (AtGLR) genes
Hiroaki Tani et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(4), 1288-1300 (2010-01-29)
The neurotransmitter glutamate is recycled through an astrocytic-neuronal glutamate-glutamine cycle in which synaptic glutamate is taken up by astrocytes, metabolized to glutamine, and transferred to neurons for conversion back to glutamate and subsequent release. The extent to which neuronal glutamate
Nitin Shirole et al.
Journal of visualized experiments : JoVE, (48)(48), doi:10-doi:10 (2011-03-16)
Recently, structural and biochemical studies have detailed many of the molecular events that occur in the ribosome during inhibition of protein synthesis by antibiotics and during nascent polypeptide synthesis. Some of these antibiotics, and regulatory nascent polypeptides mostly in the
Sevim Ozgur et al.
Molecular and cellular biology, 30(17), 4308-4323 (2010-06-30)
In eukaryotic cells, degradation of many mRNAs is initiated by removal of the poly(A) tail followed by decapping and 5'-3' exonucleolytic decay. Although the order of these events is well established, we are still lacking a mechanistic understanding of how

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