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G7516

Sigma-Aldrich

γ-Globulins from bovine blood

≥97% (agarose gel electrophoresis)

Synonym(s):

Bovine γ-Globulin

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About This Item

CAS Number:
EC Number:
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.61

biological source

bovine blood

Quality Level

assay

≥97% (agarose gel electrophoresis)

form

powder

composition

NaCl, ≤5%

solubility

0.9% NaCl: soluble 50 mg/mL

storage temp.

−20°C

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General description

Bovine gamma globulin (BGG) is an important component of the immune system of cows and other bovines. BGG is found in the blood of bovines and is primarily used in the production of medical products such as vaccines, serums, and diagnostic reagents. BGG can also be used to treat certain medical conditions, such as hepatitis B, as well as to boost immunity in humans and other animals.
The γG globulins of bovine serum are categorized by anion exchange chromatography, immunoelectrophoresis, zone electrophoresis, ultracentrifugation, and analysis of the products of papain digestion. They have properties similar to analogous components of human serum. This was determined by the methods such as: gel filtration, immunoelectrophoresis, anion exchange chromatography, ultracentrifugation, and reduction with mercaptoethanol. Fast and slow γG globulins were classified on the basis of differences in electrophoretic migration rates, chromatographic elution positions, and biological activities (complement fixation). Bovine γA was conditionally found in immunoelectrophoretic analyses of serum and chromatographic fractions.

Application

γ-globulin has been used as an immunological challenge in studies of mechanisms of immunotolerance.
Bovine γ-globulins were used to study the constituents and pH changes in protein rich hyaluronan solution affecting the bio-tribological properties of artificial articular joints. It is also used to determine immunoglobulin G in bovine colostrum and milk by direct biosensor SPR-immunoassay.
Bovine γ-globulin was used in rapid screening for monensin residues in poultry plasma by a dry reagent dissociation enhanced lanthanide fluoroimmunoassay. It was also tested for the effects of solution properties on solute and permeate flux in bovine serum albumin-IgG ultrafiltration.
Bovine γ-globulin has been used as an immunological challenge in studies of mechanisms of immunotolerance.

Preparation Note

Prepared from plasma

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Liyu He et al.
American journal of nephrology, 43(3), 179-194 (2016-04-14)
Immunoglobulin (Ig) A nephropathy (IgAN) is the xFB01;nding of immune deposits predominantly containing polymeric IgA in the glomerular mesangium on renal biopsy. Increasing evidence suggested that retinoic acid (RA) signaling selectively induces IgA isotype switching and basic leucine zipper transcription
R G Nel et al.
Biotechnology progress, 10(5), 539-542 (1994-09-01)
It has been observed that bovine serum albumin (BSA, 69,000 Da) exhibits high rejection in a pH 7.4, 0.15 M NaCl solution containing low concentrations of immuno-gamma-globulins (IgG, 155,000 Da). Although it is apparent that this phenomenon is likely due
Determination of immunoglobulin G in bovine colostrum and milk by direct biosensor SPR-immunoassay.
Indyk HE, Filonzi EL.
Journal of AOAC (Association of Official Analytical Chemists) International, 2, 386-393 (2003)
Hongdong Huang et al.
American journal of nephrology, 37(5), 472-480 (2013-05-03)
CD4+CD25+ regulatory T (Treg) cells are of critical importance for maintenance of tolerance. We showed that the number of CD4+CD25+ Treg cells was significantly lower in tonsils of patients with IgA nephropathy (IgAN); however, the function of tonsillar CD4+CD25+ Treg
S R Crooks et al.
The Analyst, 123(12), 2493-2496 (1999-08-06)
Monensin, a carboxylic acid ionophore, is commonly fed to poultry to control coccidiosis. A method for rapid analysis of unextracted poultry plasma samples has been developed based on a novel immunoassay format: one-step all-in-one dry reagent time resolved fluorimetry. All

Protocols

Guidelines for various bioassays on the MultiScreen system, which makes it possible to carry out an assay from sample incubation to scintillation counting in a 96-well plate.

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