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G8166

Sigma-Aldrich

Glucagon-Like Peptide 2 -Arg human trifluoroacetate salt

>90% (HPLC), solid

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Synonym(s):
GLP-2-Arg, Preproglucagon 126-159
Empirical Formula (Hill Notation):
C171H266N48O56S
CAS Number:
Molecular Weight:
3922.29
MDL number:
NACRES:
NA.32

Quality Level

assay

>90% (HPLC)

form

solid

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... GCG(2641)

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G3265G9416P1306
Sigma-Aldrich

G3265

Glucagon-Like Peptide I human

Sigma-Aldrich

P1306

Peptide YY human

form

solid

form

-

form

-

form

solid

UniProt accession no.

P01275

UniProt accession no.

P01275

UniProt accession no.

P01275

UniProt accession no.

P10082

Gene Information

human ... GCG(2641)

Gene Information

human ... GCG(2641)

Gene Information

human ... GCG(2641)

Gene Information

human ... PYY(5697)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Amino Acid Sequence

His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-Arg

General description

Glucagon-like peptide 2 (GLP-2) is a member of the pro-glucagon gene family which is released in small and large intestinal circulation by enteroendocrine L cells. This peptide is composed of 33 amino acids.

Application

Glucagon-Like Peptide 2 (GLP-2) -Arg human trifluoroacetate salt has been used for injection in chickens to determine the effects of GLP-2 on the weight and morphology of small intestines.

Biochem/physiol Actions

Glucagon-like peptide 2 (GLP-2) influences the functionality of gastrointestinal tract by participating in the feedback loop to the brain for the control of food intake. It also controls digestion and absorption, and has tropic effects post chemotherapy injury or surgical resection. This peptide is also responsible for epithelial cell proliferation of the small bowel. Studies in rats show that this peptide enhances the effects of the ileal-brake hormones, GLP-1 and peptide YY. It also negatively regulates gastrointestinal motility and secretion. Thus, it has potential as a therapeutic agent in short-bowel syndrome.
Glucagon-like peptide 2 is a neuropeptide that inhibits food intake when injected into the lateral ventricles of the brain and may mediate satiety. It is also a growth factor that stimulates proliferation and blocks apoptosis of intestinal epithelial cells.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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D J Drucker et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(15), 7911-7916 (1996-07-23)
Injury, inflammation, or resection of the small intestine results in severe compromise of intestinal function. Nevertheless, therapeutic strategies for enhancing growth and repair of the intestinal mucosal epithelium are currently not available. We demonstrate that nude mice bearing subcutaneous proglucagon-producing
P B Jeppesen et al.
Gastroenterology, 120(4), 806-815 (2001-03-07)
Glucagon-like peptide 2 (GLP-2) is intestinotrophic, antisecretory, and transit-modulating in rodents, and it is mainly secreted from the intestinal mucosa of the terminal ileum and colon after food ingestion. We assessed the effect of GLP-2 on the gastrointestinal function in
X F Hu et al.
Poultry science, 89(9), 1967-1974 (2010-08-17)
An experiment was conducted to determine the effect of injecting glucagon-like peptide 2 (GLP-2) on the small intestinal weight, morphology, and nutrient transporter expression in pharmacologically stressed broiler chickens. A total of 144 seven-day-old birds were fed either a basal

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