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H0915

Sigma-Aldrich

Hydroxychloroquine sulfate

≥98% (HPLC), powder

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Synonym(s):
Hydroxychloroquine sulfate, 7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline sulfate
Empirical Formula (Hill Notation):
C18H26ClN3O · H2SO4
CAS Number:
Molecular Weight:
433.95
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to off-white

solubility

H2O: >20 mg/mL

SMILES string

OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12

InChI

1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)

InChI key

JCBIVZZPXRZKTI-UHFFFAOYSA-N

Gene Information

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1 of 4

This Item
BP1100132700090527
vibrant-m

H0915

Hydroxychloroquine sulfate

vibrant-m

BP1100

Hydroxychloroquine sulfate

vibrant-m

1327000

Hydroxychloroquine sulfate

vibrant-m

90527

Hydroxychloroquine sulfate

form

powder

form

solid

form

-

form

-

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

100

solubility

H2O: >20 mg/mL

solubility

water: soluble

solubility

chloroform: practically insoluble, ethanol: practically insoluble, ether: practically insoluble, water: soluble

solubility

-

storage condition

protect from light

storage condition

-

storage condition

protect from light

storage condition

-

color

white to off-white

color

off-white

color

white to off-white

color

white to off-white

Application

Hydroxychloroquine sulfate has been used:
  • as an inhibitor of autophagy to treat cells for apoptosis assay to study the role of pirarubicin induced autophagy in bladder cancer cell line
  • to evaluate the antiviral mechanism of hydroxychloroquine against DENV-2 (dengue virus-2) infection by immunofluorescence assay
  • to inhibit lysosome fusion with the autophagosome

Biochem/physiol Actions

Hydroxychloroquine is also used for treating rheumatoid arthritis and systemic lupus erythematosus.
Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor. It is used in treating malaria.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Sigma-Aldrich

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Hydroxychloroquine sulfate

Pharmacotherapeutics for Advanced Practice, 536, 435-435 (2006)
Fluorescence Microscopy Analysis of Drug Effect on Autophagosome Formation
Stankov M, et al.
Antimicrobial agents and chemotherapy (2013)
Pirarubicin induces an autophagic cytoprotective response through suppression of the mammalian target of rapamycin signaling pathway in human bladder cancer cells
Li K, et al.
Biochemical and Biophysical Research Communications, 460(2), 380-385 (2015)
Barry Ladizinski et al.
Journal of the American Academy of Dermatology, 68(5), 749-755 (2013-02-05)
Frontal fibrosing alopecia (FFA) is a type of scarring hair loss primarily observed in postmenopausal women and characterized by fronto-tempero-parietal hairline recession, perifollicular erythema, and loss of eyebrows. The incidence is unknown, but the number of women presenting with this
The autophagy inhibitor spautin-1, either alone or combined with doxorubicin, decreases cell survival and colony formation in canine appendicular osteosarcoma cells
Schott CR, et al.
Testing, 13(10), e0206427-e0206427 (2018)

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