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H7640

Sigma-Aldrich

Heparan sulfate sodium salt from bovine kidney

powder, extracellular matrix component

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Synonym(s):
Heparitin sulfate sodium salt
CAS Number:
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

storage temp.

2-8°C

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Application

Heparan sulfate sodium salt from bovine kidney has been used:
  • to investigate its effect on proliferation of B cells
  • to monitor its role on eye development in E5 embryonic cells
  • to study its binding with exosome fibronectin in human trabecular meshwork cells using dot blot

Biochem/physiol Actions

Heparan sulphate (HS), a ubiquitous glycosaminoglycan, is a polymer of D-glucuronic acid or L-iduronic acid and D-glucosamine (GlcA) sugars. It is synthesized in the cis-Golgi as heparan. In Golgi, final heparan sulphate is synthesized in by the action of enzymes N- and O-HS-sulphotransferases and HS epimerase. The mature HS has 50 to 200 disaccharide units. It is part of the extracellular matrix (ECM) and plays a key role in the oncogenic pathway. Deregulation of heparin sulfate metabolism is implicated in cancer progression. HS is associated with the onset of infectious diseases and inflammatory conditions. HS interaction with Aβ fibrils contributes to the pathophysiology of Alzheimer′s disease.Heparan sulphate is a constituent of membrane-associated proteoglycans suggested to contribute to cell-cell adhesion.
Constituent of membrane-associated proteoglycans suggested to contribute to cell-cell adhesion

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Mechanism of fibronectin binding to human trabecular meshwork exosomes and its modulation by dexamethasone
Dismuke WM, et al.
Testing, 11(10), e0165326-e0165326 (2016)
Heparan sulfate and heparan sulfate proteoglycans in cancer initiation and progression
Nagarajan A, et al.
Frontiers in Endocrinology, 9(4), 203-231 (2018)
Towards understanding the roles of heparan sulfate proteoglycans in Alzheimer?s disease
Zhang GL, et al.
BioMed Research International, 2014(6), 555-571 (2014)
Change in embryonic eye size and retinal cell proliferation following intravitreal injection of glycosaminoglycans
Halfter W
Investigative Ophthalmology & Visual Science, 49(8), 3289-3298 (2008)
Y Tanaka et al.
The Journal of experimental medicine, 184(5), 1987-1997 (1996-11-01)
Leukocyte migration from circulation into tissue depends on leukocyte integrin-mediated adhesion to endothelium, but integrins cannot function until activated. However, it remains to be understood how tumor cells adhere to endothelium and infiltrate into underlying tissue. We studied mechanisms of

Articles

Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

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