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Key Documents

HPA048319

Sigma-Aldrich

Anti-CLDN1 antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-ILVASC, Anti-SEMP1

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About This Item

UNSPSC Code:
12352203
Human Protein Atlas Number:
NACRES:
NA.43

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

enhanced validation

orthogonal RNAseq
Learn more about Antibody Enhanced Validation

technique(s)

immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:50-1:200

immunogen sequence

KTTSYPTPRPYPKPAPSSGKDYV

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CLDN1(9076)

General description

Claudin-1 (CLDN1), also called senescence-associated epithelial membrane protein (SEMP1), is a component of tight junctions strands. It is 22 kDa protein and has four transmembrane strands. CLDN1 gene is mapped to human chromosome 3q28.

Immunogen

claudin 1

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

Biochem/physiol Actions

Claudin-1 (CLDN1) plays a key role in the tight junction barrier formation. It interacts with claudin-3 and modulates tight junctions in human airway epithelium. CLDN1 acts as a receptor for the hepatitis C virus entry and participates in the internalization of the virus. Mutation in CLDN1 gene is implicated in ichthyosis and neonatal sclerosing cholangitis (NISCH syndrome). CLDN1 is highly expressed in colon cancer.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST87501

Physical form

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Claudin association with CD81 defines hepatitis C virus entry
Harris HJ, et al.
The Journal of Biological Chemistry, jbc-M110 (2010)
Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer
Dhawan P, et al.
The Journal of Clinical Investigation, 115(7), 1765-1776 (2005)
Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes
Kirschner N, et al.
The Journal of Investigative Dermatology, 133(5), 1161-1169 (2013)
Assignment1 of Claudin-1 (CLDN1) to human chromosome 3q28? q29 with somatic cell hybrids
Halford S, et al.
Cytogenetic and genome research, 88(3-4), 217-217 (2000)
Role of claudin interactions in airway tight junctional permeability
Coyne CB, et al.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 285(5), L1166-L1178 (2003)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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