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I6160

Sigma-Aldrich

ITK (352-end), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

EMT, LYK, MG C126257, MGC126258, PSCTK2

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32
Pricing and availability is not currently available.

recombinant

expressed in baculovirus infected Sf9 cells

Quality Level

200

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

49-67 nmol/min·mg

mol wt

~53 kDa

UniProt accession no.

Q08881

shipped in

dry ice

storage temp.

−70°C

General description

ITK (IL2-inducible T-cell kinase) is a member of the Tec family of tyrosine kinases. ITK is expressed in T-cells.[1]

Biochem/physiol Actions

ITK (IL2-inducible T-cell kinase) is important for T-cell activation through the T-cell antigen receptor.[1] Absence of ITK in T cells causes impairment in TCR (T cell receptor)-mediated actin polymerization, cell polarization and signaling events associated with cytoskeletal reorganization.[2]

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
113M4811
SLBG4151V
SLBD9013V
SLBD1543V
SLBC0122V

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Lisa D Finkelstein et al.
Trends in cell biology, 14(8), 443-451 (2004-08-17)
Following stimulation, T cells undergo marked actin-dependent changes in shape that are required for productive cellular interactions and movement during immune responses. Reorganization of the actin cytoskeletal is also necessary for the formation of an immunological synapse - the convergence
Avery August et al.
The international journal of biochemistry & cell biology, 34(10), 1184-1189 (2002-07-20)
ITK and Rlk/Txk are the predominant Tec family of tyrosine kinases expressed in T cells, and are involved in T cell antigen receptor mediated activation of T cells. These kinases require prior activation of Lck, Zap-70 and PI3-kinase for efficient

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