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I8529

Sigma-Aldrich

Insulin-like Growth Factor Binding Protein-5 human

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym(s):

IGFBP-5

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About This Item

MDL number:
MFCD03457235
UNSPSC Code:
51111800
NACRES:
NA.32

biological source

human

Quality Level

100

recombinant

expressed in NSO cells

assay

>90% (SDS-PAGE)

form

lyophilized powder

potency

0.5-1.5 mg per mL ED50

mol wt

34 kDa by SDS-PAGE (reducing)
calculated mol wt ~28 kDa

packaging

pkg of 25 μg

impurities

endotoxin, tested

UniProt accession no.

P24593

storage temp.

−20°C

Gene Information

human ... IGFBP5(3488)

General description

The gene IGFBP-5 (insulin-like growth factor binding protein-5) is mapped to human chromosome 2q35.

Biochem/physiol Actions

IGFBP-5 (insulin-like growth factor binding protein-5) interacts with IGFs and thereby controls IGF activity. High levels of IGFBP5 are present in systemic sclerosis and idiopathic pulmonary fibrosis conditions. It also plays a crucial role in cancer progression.
IGFBP-5 binds to bone cells and is the predominant insulin-like growth factor binding protein in bone. When IGFBP-5 binds the extracellular matrix, it modulates IGF activity. Mouse, human, and rat IGFBP-5 share 97% homology.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA.

Analysis Note

The biological activity is measured by its ability to inhibit recombinant human IGF-1 or IGF-II on MCF-7 cells.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Baxter, R.C.
American Journal of Physiology. Endocrinology and Metabolism, 278 (2000)
V Hwa et al.
Endocrine reviews, 20(6), 761-787 (1999-12-22)
Over the last decade, the concept of an IGFBP family has been well accepted, based on structural similarities and on functional abilities to bind IGFs with high affinities. The existence of other potential IGFBPs was left open. The discovery of
Yunyun Su et al.
PloS one, 10(6), e0130546-e0130546 (2015-06-24)
Insulin-like growth factor binding protein (IGFBP)-5 levels are increased in systemic sclerosis (SSc) skin and lung. We previously reported that IGFBP-5 is a pro-fibrotic factor that induces extracellular matrix (ECM) production and deposition. Since IGFBP-5 contains a nuclear localization signal
Maya Ghoussaini et al.
Nature communications, 4, 4999-4999 (2014-09-24)
GWAS have identified a breast cancer susceptibility locus on 2q35. Here we report the fine mapping of this locus using data from 101,943 subjects from 50 case-control studies. We genotype 276 SNPs using the 'iCOGS' genotyping array and impute genotypes
Mark E Reeves et al.
PloS one, 9(7), e101679-e101679 (2014-07-10)
RASSF1C is a major isoform of the RASSF1 gene, and is emerging as an oncogene. This is in contradistinction to the RASSF1A isoform, which is an established tumor suppressor. We have previously shown that RASSF1C promotes lung cancer cell proliferation

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