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L9250

Sigma-Aldrich

Leu-Ala hydrate

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Synonym(s):

L-Leucyl-L-alanine hydrate

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About This Item

Linear Formula:
(CH3)2CHCH2CH(NH2)CONHCH(CH3)COOH · xH2O
CAS Number:
7298-84-2
Molecular Weight:
202.25 (anhydrous basis)
Beilstein/REAXYS Number:
1726165
MDL number:
MFCD00149112
UNSPSC Code:
12352209
PubChem Substance ID:
24896519
NACRES:
NA.26

Quality Level

200

assay

≥98% (TLC)

form

powder

technique(s)

ligand binding assay: suitable

color

white

storage temp.

2-8°C

SMILES string

O.CC(C)C[C@H](N)C(=O)N[C@@H](C)C(O)=O

InChI

1S/C9H18N2O3.H2O/c1-5(2)4-7(10)8(12)11-6(3)9(13)14;/h5-7H,4,10H2,1-3H3,(H,11,12)(H,13,14);1H2/t6-,7-;/m0./s1

InChI key

FTDFAGANYJVHDA-LEUCUCNGSA-N

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General description

Leucylalanine (Leu-Ala) is useful to produce non-electrolytic triorganotin (IV) derivatives (R3Sn(HL)) to study the models of metal-protein interactions.

Application

Leu-Ala hydrate has been used as a substrate in Tris-hydrochloride (HCl) buffer to analyze the leucine-alanine peptidase (LAP) activity in larvae.
Leucylalanine (Leu-Ala) is use to make non-electrolytic triorganotin(IV) derivatives (general formulae R3Sn(HL)) to study models of metal-protein interactions.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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New triorganotin (IV) derivatives of dipeptides as models for metal-protein interactions: synthesis, structural characterization and biological studies.
Nath M, Pokharia S, Eng G, Song X, Kumar A.
Spectrochimica Acta Part A: Molecular Spectroscopy, 63, 66-75 (2006)
David S Milner et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(12), 5613-5622 (2019-03-08)
Many microbes acquire metabolites in a "feeding" process where complex polymers are broken down in the environment to their subunits. The subsequent uptake of soluble metabolites by a cell, sometimes called osmotrophy, is facilitated by transporter proteins. As such, the
L P Biały et al.
Folia histochemica et cytobiologica, 40(2), 135-136 (2002-06-12)
We have used the dipeptide Leu-Ala in an attempt to prevent the formation of ubiquitin-protein conjugates in U937 cells by inhibition of cellular E3 enzymes (ubiquitin ligases). Proteasome inhibitors induce the formation of perinuclear aggregates of ubiquitinated proteins and proteasomes
Marie Terpager et al.
Journal of receptor and signal transduction research, 29(5), 235-245 (2009-09-15)
7TM receptors are easily fused to proteins such as G proteins and arrestin but because of the fact that their terminals are found on each side of the membrane they cannot be joined directly in covalent dimers. Here, we use
Arun K Ghosh et al.
Bioorganic & medicinal chemistry letters, 18(3), 1031-1036 (2008-01-09)
Structure-based design, synthesis, and biological evaluation of a series of peptidomimetic beta-secretase inhibitors incorporating hydroxyethylamine isosteres are described. We have identified inhibitor 24 which has shown exceedingly potent activity in memapsin 2 enzyme inhibitory (K(i) 1.8 nM) and cellular (IC(50)=1
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