L9908

LY-294,002 hydrochloride

from microbial (Staphylococcus roseus), ≥98% (HPLC), solid, PI3K inhibitor

• Synonym(s): 2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride
• Empirical Formula (Hill Notation): C₁₉H₁₇NO₃ · HCl
• CAS Number: 934389-88-5
• Molecular Weight: 343.80
• MDL number: MFCD00270881
• UNSPSC Code: 12352207
• PubChem Substance ID: 24278828
• NACRES: NA.77

Properties

• biological source: microbial (Staphylococcus roseus)
• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• color: white to off-white
• solubility: DMSO: >5 mg/mL; H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: O=C1C=C(Oc2c1cccc2-c3ccccc3)N4CCOCC4
• InChI: 1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
• InChI key: CZQHHVNHHHRRDU-UHFFFAOYSA-N

Description

General description

LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility.

Application

LY-294,002 hydrochloride has been used in the inhibition of:

• phosphoinositide 3-kinase (PI3K) in human lung cancer cell line
• autophagy in mesenchymal stem cells (MSCs).
• serine/threonine-specific protein kinase (AKT) signaling in fibroblasts and cardiac cells.

Biochem/physiol Actions

Specific cell permeable phosphatidylinositol 3-kinase inhibitor.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide and Kinase Phosphatase Biology research. Discover more featured Cyclic Nucleotide and Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the G Proteins (Heterotrimeric) and Phosphoinositide Kinases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)