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Melittin from honey bee venom

≥85% (HPLC)

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Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
MDL number:
PubChem Substance ID:

biological source

animal (Apis mellifera)

Quality Level


≥85% (HPLC)


lyophilized powder

mol wt

~_2.8 kDa


water: 5.00-5.20 mg/mL, clear, colorless to faintly yellow

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

foreign activity

Phospholipase A2 ≤0.5%

mode of action

cell membrane | interferes

storage temp.


SMILES string




InChI key


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Amino Acid Sequence


General description

Chemical structure: peptide
Melittin is hydrophobic in nature except for a region with Lys-Arg-Lys-Arg sequence near C-terminal end. This structural characteristic makes melittin a highly surface-active and a powerful, direct haemolytic agent.† The encoded protein containins 26 amino acids. Monomeric form of melittin has a molecular weight of 2,840 Daltons and tetrameric form has molecular weight of approximately 12,500 Daltons.


Melittin from honey bee venom has been used:
  • In 3-(4, 5-dimethyl thiazol-2-yl)-2,5diphenyl tetrazolium bromide (MTT) assay to determine its cytotoxicity effect on the growth of human cell lines.
  • To study the anti-microbial activity of melittin on the growth of Borrelia burgdorferi in in vitro conditions.
  • As a positive control in hemolysis assay and as a cytotoxic agent against HeLa cells.

Biochem/physiol Actions

Melittin acts as an anti-coagulating protein by increasing the time of blood clotting in vitro. Melittin inhibits the activity of S100 calcium-binding protein B (S100B) and plays a vital role in Epilepsy treatment.
Binds calmodulin in a Ca2+-dependent manner; inhibits Na+-K+-ATPase.

Other Notes

The principle hemolytic component of honeybee venom.


Skull and crossbones



Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Oral

Storage Class

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials




Not applicable


Not applicable

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Customers Also Viewed

Slide 1 of 4

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Selective cytotoxicity Assay in anticancer drug of Melittin Isolated from
Bee Venom (Apis cerana indica) to several human cell lines: HeLa,
WiDr and Vero.
Plasay M
Journal of Chemical and Pharmaceutical Sciences , 9:4, 2674-2676 (2016)
Ipsita Saha et al.
Viruses, 13(10) (2021-10-27)
Immature HIV virions harbor a lattice of Gag molecules with significant ordering in CA-NTD, CA-CTD and SP1 regions. This ordering plays a major role during HIV maturation. To test the condition in which the Gag lattice forms in vivo, we
The antimicrobial agent melittin exhibits powerful in vitro inhibitory effects on the Lyme disease spirochete.
Lubke LL and Garon CF
Clinical Infectious Diseases, suppl 1, S48-S51 (1997)
Structural and Dynamic Insights into S100B Protein Activity Inhibition by Melittin for the Treatment of Epilepsy
Verma N
International Journal of Computer Applications, 55-60 (2013)
Gonen Golani et al.
Nature communications, 12(1), 495-495 (2021-01-23)
Myomerger is a muscle-specific membrane protein involved in formation of multinucleated muscle cells by mediating the transition from the early hemifusion stage to complete fusion. Here, we considered the physical mechanism of the Myomerger action based on the hypothesis that


Ribosomally synthesized antimicrobial peptides are a promising focus in antibiotic research amidst bacterial resistance and emerging infectious diseases.

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