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N4267

Sigma-Aldrich

Neurokinin A

≥97% (HPLC)

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Synonym(s):
α-Neurokinin, Neuromedin L, Substance K
Linear Formula:
C50H79N13O15S
CAS Number:
Molecular Weight:
1133.32
MDL number:
PubChem Substance ID:
NACRES:
NA.32

Quality Level

assay

≥97% (HPLC)

form

powder

composition

Peptide content, ≥70%

UniProt accession no.

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CO)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)Cc2cnc[nH]2)C(C)O)C(C)C)C(N)=O

InChI

1S/C50H80N14O14S/c1-26(2)18-34(45(73)58-32(42(53)70)15-17-79-6)57-38(67)23-55-49(77)40(27(3)4)63-47(75)35(19-29-12-8-7-9-13-29)60-48(76)37(24-65)62-46(74)36(21-39(68)69)61-50(78)41(28(5)66)64-44(72)33(14-10-11-16-51)59-43(71)31(52)20-30-22-54-25-56-30/h7-9,12-13,22,25-28,31-37,40-41,65-66H,10-11,14-21,23-24,51-52H2,1-6H3,(H2,53,70)(H,54,56)(H,55,77)(H,57,67)(H,58,73)(H,59,71)(H,60,76)(H,61,78)(H,62,74)(H,63,75)(H,64,72)(H,68,69)

InChI key

HEAUFJZALFKPBA-UHFFFAOYSA-N

Gene Information

human ... TAC1(6863)

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1 of 4

This Item
N4143E9012E9137
Neurokinin A ≥97% (HPLC)

N4267

Neurokinin A

Neurokinin B ≥95% (HPLC)

N4143

Neurokinin B

Endothelin 2 human ≥97% (HPLC), powder

E9012

Endothelin 2 human

Endothelin 3 human, rat ≥97% (HPLC), powder

E9137

Endothelin 3 human, rat

form

powder

form

powder

form

powder

form

powder

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

composition

Peptide content, ≥70%

composition

-

composition

-

composition

Peptide content, ≥60%

UniProt accession no.

P20366

UniProt accession no.

Q9UHF0

UniProt accession no.

P20800

UniProt accession no.

P13207, P14138

Amino Acid Sequence

His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2

General description

Neurokinin A is an 11 amino acid peptide. It is a member of tachykinin family, which includes neurokinin A, neurokinin B, neuropeptide K, neuropeptide Y and hemokinin-1. The gene encoding neurokinin A is localized on human chromosome 7q21.3.

Biochem/physiol Actions

Neurokinin A improves the multiplication and paracrine ability of stem cells acquired from adipose in vitro. It participates in the movement of several organ tracts, triggers glandular secretion and controls autonomic reflexes. Neurokinin A plays an important role in neuroimmune and systemic autoimmune/inflammatory conditions like multiple sclerosis (MS), rheumatoid arthritis, inflammatory bowel disease and also in infections and cancer.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Reciprocal Regulation of Substance P and IL-12/IL-23 and the Associated Cytokines, IFN?/IL-17: A Perspective on the Relevance of This Interaction to Multiple Sclerosis
Janek V
Journal of Neuroimmune Pharmacology (2015)
Y Chang et al.
The Journal of pharmacology and experimental therapeutics, 294(1), 147-154 (2000-06-28)
Selective tachykinin agonists were used to identify cardiac and coronary responses mediated by specific tachykinin receptor subtypes in isolated, perfused guinea pig hearts. Receptor desensitization with selective agonists and blockade with selective antagonists were used to determine the role of
Floriane Pailleux et al.
Neurochemical research, 37(12), 2678-2685 (2012-08-11)
Vanilloid receptors have a central role in the processing of nociceptive stimuli. TRPV1 null mice showed significant decrease in response to heat noxious stimuli. However, thermal sensitivity is still present suggesting that the TRPV1 is not an exclusive transducer of
Delineation of a de novo 7q21.3q31.1 Deletion by
CGH-SNP Arrays in a Girl with Multiple Congenital
Anomalies Including Severe Glaucoma
L. Martinez-Jacobo
Molecular Syndromology (2013)
C A Rizzo et al.
Neuropeptides, 33(1), 27-34 (2000-02-05)
Neurokinins (NK) are implicated in airway pathology. Selective NK(2)-receptor antagonists may prove therapeutic in airway disease. We studied Neurokinin A (NKA) responses of isolated, cryopreserved cynomolgus monkey, fresh guinea pig, and fresh and cryopreserved human airways. NKA contracted monkey trachea

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