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N5017

Sigma-Aldrich

Neuropeptide Y human

≥95% (HPLC), powder, synthetic

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Synonym(s):
NPY, hNPY
Empirical Formula (Hill Notation):
C189H285N55O57S
CAS Number:
Molecular Weight:
4271.68
MDL number:
NACRES:
NA.32

biological source

synthetic

Quality Level

assay

≥95% (HPLC)

form

powder

color

white

solubility

H2O: 1 mg/mL

UniProt accession no.

storage temp.

−20°C

InChI

1S/C189H285N55O57S/c1-15-93(7)148(179(295)234-128(81-140(193)254)168(284)226-123(74-92(5)6)171(287)239-149(94(8)16-2)180(296)240-150(99(13)247)181(297)222-115(31-22-67-208-189(202)203)156(272)220-117(56-59-139(192)253)161(277)218-113(29-20-65-206-187(198)199)157(273)224-121(151(195)267)76-101-38-48-107(249)49-39-101)238-172(288)126(79-104-44-54-110(252)55-45-104)229-167(283)127(80-105-86-204-90-210-105)230-159(275)114(30-21-66-207-188(200)201)219-164(280)122(73-91(3)4)225-154(270)96(10)212-173(289)133(88-245)236-166(282)125(78-103-42-52-109(251)53-43-103)228-165(281)124(77-102-40-50-108(250)51-41-102)227-158(274)112(28-19-64-205-186(196)197)216-152(268)95(9)211-155(271)119(62-72-302-14)221-169(285)130(84-146(263)264)232-162(278)118(58-61-144(259)260)217-153(269)97(11)213-176(292)136-33-24-68-241(136)182(298)98(12)214-163(279)129(83-145(261)262)231-160(276)116(57-60-143(257)258)215-142(256)87-209-175(291)135-32-23-70-243(135)185(301)132(82-141(194)255)235-170(286)131(85-147(265)266)233-177(293)138-35-26-71-244(138)184(300)120(27-17-18-63-190)223-174(290)134(89-246)237-178(294)137-34-25-69-242(137)183(299)111(191)75-100-36-46-106(248)47-37-100/h36-55,86,90-99,111-138,148-150,245-252H,15-35,56-85,87-89,190-191H2,1-14H3,(H2,192,253)(H2,193,254)(H2,194,255)(H2,195,267)(H,204,210)(H,209,291)(H,211,271)(H,212,289)(H,213,292)(H,214,279)(H,215,256)(H,216,268)(H,217,269)(H,218,277)(H,219,280)(H,220,272)(H,221,285)(H,222,297)(H,223,290)(H,224,273)(H,225,270)(H,226,284)(H,227,274)(H,228,281)(H,229,283)(H,230,275)(H,231,276)(H,232,278)(H,233,293)(H,234,295)(H,235,286)(H,236,282)(H,237,294)(H,238,288)(H,239,287)(H,240,296)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H,265,266)(H4,196,197,205)(H4,198,199,206)(H4,200,201,207)(H4,202,203,208)/t93-,94-,95-,96-,97-,98-,99+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,148-,149-,150-/m0/s1

InChI key

XKWCTHKJQNUFOQ-HRPSIEBRSA-N

Gene Information

human ... NPY(4852)

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1 of 4

This Item
N9407PC223LN9528
Sigma-Aldrich

N5017

Neuropeptide Y human

Anti-Neuropeptide Y Rabbit pAb lyophilized, Calbiochem®

PC223L

Anti-Neuropeptide Y Rabbit pAb

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

-

assay

-

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

200

form

powder

form

powder

form

lyophilized

form

-

UniProt accession no.

P01303

UniProt accession no.

P01303

UniProt accession no.

-

UniProt accession no.

P01303

Gene Information

human ... NPY(4852)

Gene Information

human ... NPY(4852)

Gene Information

human ... NPY(4852)

Gene Information

rat ... Npy(24604)

Amino Acid Sequence

Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2

General description

Neuropeptide Y is a regulatory molecule encoded by a gene mapped to human chromosome 7p15. Neuropeptide Y is a 36 amino acid protein with C-terminal α-amide structure. It is ubiquitously distributed in heart and brain, but at high levels in paraventricular hypothalamic nucleus, hypothalamic arcuate nucleus, suprachiasmatic nucleus, median eminence, dorsomedial, hypothalamic nucleus, paraventricular thalamic nuclei. NPY is a member of antimicrobial peptide family, which also include dermaseptins, cecropins or magainins.

Application

Neuropeptide Y (NPY) human has been used:
  • to study the effect of antiepileptic effects on pentylenetetrazole (PTZ) rats.
  • as a standard in high-performance liquid chromatography (HPLC) standard and control to verify specificity of the antibodies.
  • to study the effect of NPY on motor and electroencephalographic (EEG) seizures induced by kainic acid.

Biochem/physiol Actions

Neuropeptide Y (NPY) plays a vital role in various processes including feeding behaviour, anxiety, epilepsy, circadian, as well as rhythm memory processing, sleep, pain and drug addiction. In addition, it is also implicated in regulation of appetite, body weight and obesity. It controls central endocrine secretion and has potent vasoactive effects on the cardiovascular system. NPY is involved in the pathogenesis of atherosclerosis and coronary artery disease. NPY exhibits antimicrobial activity against Cryptococcus neoformans, Candida albicans and Arthroderma simii.
Vasoconstrictor; brain peptide that inhibits Ca2+-activated K+ channels in vascular smooth muscle. Implicated in the control of blood pressure, sexual behavior and food intake. Inhibits cholecystokinin- and secretin-stimulated pancreatic secretion.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Raksha Bhat et al.
Scientific reports, 12(1), 1972-1972 (2022-02-06)
G Protein-Coupled Receptors (GPCRs) represent the largest superfamily of cell-surface proteins. However, the expression and function of majority of GPCRs remain unexplored in breast cancer (BC). We interrogated the expression and phosphorylation status of 398 non-sensory GPCRs using the landmark
Wufei Dai et al.
Scientific reports, 9(1), 9500-9500 (2019-07-03)
Neuropeptide Y (NPY) is an abundant neuropeptide in the mammalian central and peripheral nervous systems. Transgenic mice overexpressing NPY in noradrenergic neurons have increased level of hepatic triglycerides, fatty acids and cholesterol, which contributed to the development of hepatosteatosis. However
Enhancement of antimicrobial activity of neuropeptide Y by N-terminal truncation.
Shimizu M
Antimicrobial Agents and Chemotherapy, 42(10), 2745-2746 (1998)
Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors.
Woldbye DP
Nature Medicine, 3(7), 761-764 (1997)
Antiepileptic effects of NPY on pentylenetetrazole seizures.
Woldbye DP
Regulatory Peptides, 75-76, 279-282 (1998)

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