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N5504

Sigma-Aldrich

Naphazoline hydrochloride

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Synonym(s):
2-(1-Naphthylmethyl)imidazoline hydrochloride
Empirical Formula (Hill Notation):
C14H14N2 · HCl
CAS Number:
Molecular Weight:
246.74
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

form

powder

originator

Allergan

SMILES string

Cl.C1CN=C(Cc2cccc3ccccc23)N1

InChI

1S/C14H14N2.ClH/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;/h1-7H,8-10H2,(H,15,16);1H

InChI key

DJDFFEBSKJCGHC-UHFFFAOYSA-N

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1 of 4

This Item
1457006N0080000PHR1836
Naphazoline hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1457006

Naphazoline hydrochloride

Naphazoline hydrochloride European Pharmacopoeia (EP) Reference Standard

N0080000

Naphazoline hydrochloride

Naphazoline hydrochloride Pharmaceutical Secondary Standard; Certified Reference Materialr

Supelco

PHR1836

Naphazoline hydrochloride

originator

Allergan

originator

-

originator

-

originator

-

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

300

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Biochem/physiol Actions

Naphazoline hydrochloride is a sympathomimetic agent. It is also considered as a conjunctival decongestant.
α-adrenoceptor agonist; imidazoline receptor agonist; vasoconstrictor.

Features and Benefits

This compound was developed by Allergan. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Yuriko Nagane et al.
Muscle & nerve, 44(1), 41-44 (2011-04-15)
When treating ocular myasthenia gravis (MG), the risk/benefit profile of corticosteroids is unclear, and acetylcholinesterase inhibitors are not very effective. We examined the efficacy of topical naphazoline in the treatment of myasthenic blepharoptosis. Sixty MG patients with blepharoptosis (32 with
Nan-Nan Wang et al.
Luminescence : the journal of biological and chemical luminescence, 24(3), 178-182 (2009-03-03)
A sensitive and simple flow-injection chemiluminescence (FI-CL) method, which was based on the CL intensity generated from the redoxreaction of potassium permanganate (KMnO4)-formaldehyde in vitriol (H2SO4) medium, has been developed, validated and applied for the determination of naphazoline hydrochloride and
Shizhong Zhu et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 98, 142-147 (2012-09-22)
The fluorescence and ultraviolet spectroscopy were explored to study the interaction between Naphazoline hydrochloride (Naphcon) and bovine serum albumin (BSA) at three different temperatures (292, 301, and 310 K) under imitated physiological conditions. The quenching mechanism of BSA by Naphacon
Eman Y Z Frag et al.
The Analyst, 136(2), 332-339 (2010-10-21)
This paper describes the development of screen-printed (SPE) and carbon paste (CPE) sensors for the rapid and sensitive quantification of naphazoline hydrochloride (NPZ) in pharmaceutical formulations. This work compares the electroactivity of conventional carbon paste and screen-printed carbon paste electrodes
Robert Fuchs et al.
Experimental cell research, 317(20), 2969-2980 (2011-08-20)
Even though the erythroleukemia cell lines K562 and HEL do not express α1-adrenoceptors, some α1-adrenergic drugs influence both survival and differentiation of these cell lines. Since Ca2+ is closely related to cellular homeostasis, we examined the capacity of α1-adrenergic drugs

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