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Key Documents

N6877

Sigma-Aldrich

L-Norleucine

≥98% (TLC)

Synonym(s):

(S)-(+)-2-Aminohexanoic acid, (S)-2-Aminocaproic acid

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1 ML
$187.00
0.1 ML
$214.00
0.1 ML
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7 ML
$472.00
0.5 ML
$617.00
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$953.00

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1 ML
$187.00
0.1 ML
$214.00
0.1 ML
$214.00
7 ML
$472.00
0.5 ML
$617.00
1 ML
$953.00

About This Item

Linear Formula:
CH3(CH2)3CH(NH2)CO2H
CAS Number:
Molecular Weight:
131.17
Beilstein/REAXYS Number:
1721750
EC Number:
MDL number:
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

$187.00


Estimated to ship onMarch 22, 2025


Request a Bulk Order

Quality Level

assay

≥98% (TLC)

form

powder

color

white

mp

>300 °C (lit.)

application(s)

detection

SMILES string

CCCC[C@H](N)C(O)=O

InChI

1S/C6H13NO2/c1-2-3-4-5(7)6(8)9/h5H,2-4,7H2,1H3,(H,8,9)/t5-/m0/s1

InChI key

LRQKBLKVPFOOQJ-YFKPBYRVSA-N

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Show Differences

1 of 4

This Item
114R-1102R-1123R-2
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

clone

EP3622, monoclonal

clone

EPR3653, monoclonal

clone

EP222, monoclonal

clone

EP75, monoclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

application


  • l-norleucine on high glucose-induced insulin sensitivity and mitochondrial function in skeletal muscle cells. This study explores the beneficial effects of L-Norleucine on insulin sensitivity and mitochondrial function, underlining its potential in metabolic pathway research and its application in managing diabetes through targeted amino acid therapy (Ding et al., 2024).

Biochem/physiol Actions

L-Norleucine is a synthetic amino acid commonly used as an internal standard.

Other Notes

Non-essential amino acid.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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    Luana Bontempo et al.
    Food chemistry, 318, 126426-126426 (2020-03-07)
    Until now, there has been a lack of analytical methods that can reliably verify the authenticity of organically grown plants and derived organic food products. In this study, stable isotope ratio analysis of hydrogen (H, δ2H), carbon (C, δ13C), nitrogen
    Amar R Mohite et al.
    The Journal of organic chemistry, 77(12), 5423-5428 (2012-05-24)
    A short, concise synthesis of enantiopure, side chain-modified α-amino acids such as 4-oxo-L-norvaline, 6-oxo-L-homonorleucine, and 5-cis-alkyl prolines is described. Knoevenagel condensation of l-aminocarboxylate-derived β-ketoesters with aldehydes followed by reductive decarboxylation results in unnatural α-amino acids in good yield. A fluorescent
    L M FitzGerald et al.
    Australian veterinary journal, 89(3), 95-100 (2011-02-18)
    Four dogs presented with clinical signs of severe hepatic disease after consuming a commercial camel meat diet. Laboratory investigation revealed evidence of severe liver disease, including markedly increased serum alanine aminotransferase (ALT) activity and total bilirubin concentration, and prolonged clotting
    Haiyan Wei et al.
    The journal of physical chemistry. B, 114(36), 11820-11826 (2010-08-24)
    Following the studies of urea denaturation of β-hairpins using molecular dynamics, in this paper, molecular dynamics simulations of two peptides, a 35 residue three helix bundle villin headpiece protein HP-35 and its doubly norleucine-substituent mutant (Lys24Nle/Lys29Nle) HP-35 NleNle, were undertaken
    Samy Boulos et al.
    Frontiers in nutrition, 7, 89-89 (2020-08-06)
    With an increasing worldwide demand for animal protein, insects are becoming a promising sustainable option for meat protein replacement. However, reported protein contents of insects are often overestimated when calculated as "crude protein" = 6.25 × nitrogen content (N), compared

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