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N7382

Nitrosomorpholine

Synonym(s):

NMOR

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About This Item

Empirical Formula (Hill Notation):
C4H8N2O2
CAS Number:
59-89-2
Molecular Weight:
116.12
NACRES:
NA.25
PubChem Substance ID:
24897824
UNSPSC Code:
41116105
MDL number:
MFCD00039710
Form:
solid
Quality level:
100

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InChI

1S/C4H8N2O2/c7-5-6-1-3-8-4-2-6/h1-4H2

SMILES string

O=NN1CCOCC1

InChI key

ZKXDGKXYMTYWTB-UHFFFAOYSA-N

form

solid

Quality Level

100

Biochem/physiol Actions

Tumor initiator in rodent liver, trachea, nasal cavity, esophagus, kidney, lung, and thyroid.

Packaging

Bulk package

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1B - Muta. 2 - STOT RE 1

target_organs

Liver

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX6070
MKCT1742
MKCR8362
MKCN2923
MKCN2922

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W Lijinsky et al.
Carcinogenesis, 3(8), 911-915 (1982-01-01)
A comparison was made of the carcinogenic effectiveness of some cyclic nitrosamines containing oxygen in the ring. The compounds were administered to F344 rats at approximately equimolar concentrations in drinking water. Nitrosomorpholine, nitroso-1,3-oxazolidine and nitrosotetrahydro-1,3-oxazine were of similar potency and
W Lijinsky et al.
In vivo (Athens, Greece), 5(2), 85-89 (1991-03-01)
A number of nitrosamines that have been studied by administration to rats as solutions in drinking water have been examined by gavage administration of similar doses, for assessment of the role of pharmacokinetics in organ-specific carcinogenesis. Methylnitrosoethylamine was more effective
Jutta Groos et al.
Mathematical biosciences, 202(2), 248-268 (2006-04-11)
Several hypotheses are established to describe the formation and progression of foci of altered hepatocytes (FAH). A common model of hepatocarcinogenesis is the mutation model (MM), which is based on the assumption that cells have to undergo multiple successive changes
Yong-Cang Wang et al.
Hepato-gastroenterology, 58(112), 2032-2035 (2012-01-12)
Concern that much controversy exists with respect to the role of estrogen in hepatocarcinogenesis prompted us to examine the effect of estrogen, at physiological concentrations, on our established HCC rat model induced by diethylnitrosamine and N-nitrosomorpholine. Female Sprague-Dawley rats were
Olga Teufelhofer et al.
Electrophoresis, 27(20), 4112-4120 (2006-10-21)
Comparative proteome data of normal and diseased tissue samples are difficult to interpret. Proteins detected in tissues are derived from different cell types and blood constituents. Pathologic or toxicant-induced aberrations may affect the proteome profile of tissues in several ways
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