Skip to Content
MilliporeSigma
All Photos(2)

Documents

N8161

Sigma-Aldrich

NS309

≥98% (HPLC), solid

Sign Into View Organizational & Contract Pricing

Synonym(s):
3-Oxime-6,7-dichloro-1H-indole-2,3-dione
Empirical Formula (Hill Notation):
C8H4Cl2N2O2
CAS Number:
Molecular Weight:
231.04
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

assay

≥98% (HPLC)

form

solid

color

yellow

solubility

DMSO: 22 mg/mL

storage temp.

2-8°C

SMILES string

O\N=C1\C(=O)Nc2c(Cl)c(Cl)ccc12

InChI

1S/C8H4Cl2N2O2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12-14/h1-2,14H,(H,11,12,13)

InChI key

CVOUSAVHMDXCKG-UHFFFAOYSA-N

Biochem/physiol Actions

NS309 is a Ca2+-activated IK/SK potassium channel activator.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Caution

air sensitive

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Cara C Rada et al.
American journal of physiology. Endocrinology and metabolism, 307(10), E935-E943 (2014-09-25)
Proper placental perfusion is essential for fetal exchange of oxygen, nutrients, and waste with the maternal circulation. Impairment of uteroplacental vascular function can lead to pregnancy complications, including preeclampsia and intrauterine growth restriction (IUGR). Potassium channels have been recognized as
Kanwal Sakhi et al.
The Journal of physiology, 592(4), 587-603 (2013-11-20)
Intrinsic daily or circadian rhythms arise through the outputs of the master circadian clock in the brain's suprachiasmatic nuclei (SCN) as well as circadian oscillators in other brain sites and peripheral tissues. SCN neurones contain an intracellular molecular clock that
Jackson T Fontaine et al.
Mechanisms of ageing and development, 192, 111389-111389 (2020-11-01)
Vascular cognitive impairment, the second most common cause of dementia, profoundly affects hippocampal-dependent functions. However, while the growing literature covers complex neuronal interactions, little is known about the sustaining hippocampal microcirculation. Here we examined vasoconstriction to physiological pressures of hippocampal
Fan-Fan Li et al.
Placenta, 58, 9-16 (2017-10-01)
Excessive constriction of placental chorionic plate arteries (CPAs) may be associated with preeclampsia (PE). Nitric oxide (NO) as well as intermediate and small Ca The location of IK IK This study provides evidence that dysregulated IK
Jensen, B.S., et al.
Abstr. Soc. Neurosci, 2003, 367-367 null

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service