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O0391

Sigma-Aldrich

Olopatadine hydrochloride

≥98% (HPLC)

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Synonym(s):
(11Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride, AL-4943A, KW-4679, Opatanol, Patanol
Empirical Formula (Hill Notation):
C21H23NO3·HCl
CAS Number:
Molecular Weight:
373.87
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

solid

solubility

H2O: ≥20 mg/mL

storage temp.

room temp

SMILES string

Cl.CN(C)CC\C=C1\c2ccccc2COc3ccc(CC(O)=O)cc13

InChI

1S/C21H23NO3.ClH/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24;/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24);1H/b18-8-;

InChI key

HVRLZEKDTUEKQH-NOILCQHBSA-N

Gene Information

human ... HRH1(3269)

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1 of 4

This Item
1478403D4526O1385
vibrant-m

O0391

Olopatadine hydrochloride

vibrant-m

1478403

Olopatadine hydrochloride

vibrant-m

D4526

Doxepin hydrochloride

vibrant-m

O1385

Ozagrel hydrochloride hydrate

form

solid

form

-

form

powder

form

solid

Quality Level

100

Quality Level

-

Quality Level

200

Quality Level

100

solubility

H2O: ≥20 mg/mL

solubility

-

solubility

1 M HCl: 50 mg/mL, H2O: soluble

solubility

H2O: soluble

storage temp.

room temp

storage temp.

-

storage temp.

-

storage temp.

room temp

Gene Information

human ... HRH1(3269)

Gene Information

human ... HRH1(3269)

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133), HRH1(3269), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)

Gene Information

-

Biochem/physiol Actions

Olopatadine is a histamine H1 receptor antagonist and mast cell stabilizer. The low level of occupancy H1 receptors in the brain explains the low sedation effect of olopatidine. It is believed that olopatidine is a substrate for P-glycoprotein, which limits its brain penetration.

pictograms

Skull and crossbonesEnvironment

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Eli O Meltzer et al.
Allergy and asthma proceedings, 32(3), 213-220 (2011-04-12)
Allergic rhinitis (AR) is highly prevalent in children. Olopatadine, 0.6% nasal spray (olopatadine) is approved for the relief of seasonal allergic rhinitis (SAR) symptoms in children 6 years of age and older. The objective of this study is to provide
Fuad M Baroody et al.
American journal of rhinology & allergy, 27(1), 48-53 (2013-02-15)
Nasal allergen challenge (NAC) leads to a nasal ocular reflex, which is augmented by allergic inflammation. This study was designed to confirm our previous observation that an intranasal steroid inhibits the nasal ocular reflex and to show that histamine does
Masahiko Shimura et al.
American journal of ophthalmology, 151(4), 697-702 (2011-01-25)
To evaluate the effectiveness of pre-seasonal treatment with topical olopatadine on the reduction of clinical symptoms of seasonal allergic conjunctivitis (SAC). Prospective interventional case series. Eleven patients with SAC received topical olopatadine in one eye at least two weeks before
Yukari Okubo et al.
The Journal of dermatological treatment, 24(2), 153-160 (2011-08-04)
An increased dose of the prescribed drug or a change of the drug is recommended in the treatment for the patients with urticaria refractory to the standard dose of antihistamines. Efficacy and safety of doubling the dose of cetirizine were
Hiroyuki Kamei et al.
Archives of dermatological research, 304(4), 263-272 (2011-12-02)
Since most first-generation antihistamines have undesirable sedative effects on the central nervous systems (CNS), newer (second-generation) antihistamines have been developed to improve patients' quality of life. However, there are few reports that directly compare the antihistaminic efficacy and impairment of

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