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P0040

Sigma-Aldrich

PP1

≥98% (HPLC)

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Synonym(s):
4-Amino-5-(methylphenyl)-7-(t-butyl)pyrazolo-(3,4-d)pyrimidine
Empirical Formula (Hill Notation):
C16H19N5
CAS Number:
Molecular Weight:
281.36
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >20 mg/mL

storage temp.

room temp

SMILES string

Cc1ccc(cc1)-c2nn(c3ncnc(N)c23)C(C)(C)C

InChI

1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)

InChI key

ZVPDNRVYHLRXLX-UHFFFAOYSA-N

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This Item
P0042P0036PZ0357
PP1 ≥98% (HPLC)

P0040

PP1

PP2 ≥98% (HPLC)

P0042

PP2

PP121 ≥98% (HPLC)

P0036

PP121

PF-06412562 ≥98% (HPLC)

PZ0357

PF-06412562

form

powder

form

powder

form

powder

form

powder

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

solubility

DMSO: >20 mg/mL

solubility

DMSO: >10 mg/mL

solubility

DMSO: >10 mg/mL

solubility

DMSO: 30 mg/mL, clear

color

white to off-white

color

white to off-white

color

off-white

color

white to beige

Application

PP1 has been used as:
  • an inhibitor of sarcoma (Src) family kinases (SFK) like hematopoietic cell kinase (hck) and fyn
  • a selective Src tyrosine kinase inhibitor in hippocampal neuronal cultures to test its effect on neurite growth
  • a Src-kinase blocker to test its effect on brimonidine (BMD)-induced phosphorylation in extracellular signal-activated kinases(ERK1/2)

Biochem/physiol Actions

PP1 is a pyrazolopyrimidine compound that acts as a competitive inhibitor of adenosine triphosphate (ATP) binding. It also inhibits protein tyrosine kinase (PTK6) and may be useful in the therapeutic management of PTK6 positive based breast cancer malignancy.
PP1 is a potent and selective Src family protein tyrosine kinase inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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