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P1750

Sigma-Aldrich

Pancreatin from porcine pancreas

4 × USP specifications

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Synonym(s):
Pancreatin from hog pancreas
CAS Number:
EC Number:
MDL number:
NACRES:
NA.54

Agency

USP (specifications)

Quality Level

form

powder

specific activity

4 × USP specifications

contains

lactose or sucrose as extender (The sucrose used might contain up to 3.25% starch.)

storage temp.

−20°C

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This Item
P1625P3292P7545
specific activity

4 × USP specifications

specific activity

≥3 × USP specifications

specific activity

4 × USP specifications

specific activity

8 × USP specifications

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

agency

USP (specifications)

agency

USP (specifications)

agency

USP (specifications)

agency

-

contains

lactose or sucrose as extender (The sucrose used might contain up to 3.25% starch.)

contains

-

contains

lactose or sucrose as extender (The sucrose used might contain up to 3.25% starch.)

contains

lactose as extender

Application

Pancreatin from porcine pancreas has been used:
  • for a study to assess the treatment of steatorrhea by lipase supplementation therapy
  • for a study to investigate treatment options for pancreatic diabetes in patients experiencing the decompensated stage of chronic pancreatitis
  • to safely and effectively remove formalin-fixed tissues from arterial grafts without causing structural damage and loss in fiber integrity
  • to assess cleavage by digestive enzymes.
  • for in vitro digestibility analysis and to test the sensitivities of cellulolytic bacteria inhibitors.
  • along with amyloglucosidase for the in vitro digestion of starch in food samples.

Biochem/physiol Actions

Pancreatin contains enzymatic components including trypsin, amylase and lipase, ribonuclease, and protease, produced by the exocrine cells of the porcine pancreas. This combination of enzymes allows it to hydrolyze proteins, starch and fats. Pancreatin will convert not less than 25 times its weight of potato starch into soluble carbohydrates in 5 minutes in water at 40°C, will digest not less than 25 times its weight of casein in 60 minutes at pH 7.5 at 40°C and will release not less than microequivalents of acid per min per mg pancreatin from olive oil at pH 9.0 at 37°C.

Pictograms

Exclamation markHealth hazard

Signal Word

Danger

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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David C Whitcomb et al.
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A primary function of the pancreas is to produce digestive enzymes that are delivered to the small intestine for the hydrolysis of complex nutrients. Much of our understanding of digestive enzymes comes from studies in animals. New technologies and the
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Pancreatic steatorrhea and pancreatic diabetes are the dominant symptoms of patients in the decompensated stage of chronic pancreatitis (CP). In this stage, the nutritional state is greatly disturbed and hypoglycemia and labile infection are involved. Pancreatic enzyme replacement therapy is
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Treatment of steatorrhea by lipase supplementation therapy has become more successful in the last decade due to better understanding of the physiology and pathophysiology of the digestive process. Porcine lipase has been the therapeutic standard for several decades and will

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